NCT05327920Completed
An Observational Study to Assess the Impact of Upadacitinib in Adult Hungarian Participants With Moderate to Severe Rheumatoid Arthritis (RA) in Real-World Practice
Impact of UPaDacitinib Treatment on inflAmmaTion, AchiEvement of Treatment Targets and Health-related Quality of Life, Work Ability and Healthcare Resource Utilization in Moderate to Severe Rheumatoid Arthritis Patients in Hungarian Real-world Practice
Source: ClinicalTrials.gov · Last updated 14 Mar 2025
Brief summary (registry, in English)
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the impact of upadacitinib treatment on achievement of remission and low disease activity in moderate to severe RA Hungarian patients in the real-world setting. Upadacitinib is an approved drug for the treatment of adults with moderately to severely active RA. Adult participants with moderate-to-severe RA will be enrolled. Around 90 participants who are prescribed upadacitinib in routine clinical practice will be enrolled in the study in approximately 8 sites in Hungary. Participants will receive upadacitinib as prescribed by the physician and will be followed for approximately 12 months. There will be no additional burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic and only data which are routinely collected during a regular visit will be utilized for this study.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 93 (actual)
- First submitted
- 12 Apr 2022
- Start date
- 20 Apr 2022
- Primary completion date
- 22 Apr 2024
- Lead sponsor
- AbbVie
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT05327920
What you commit to
- Study type: Observational
- Participants enrolled: 93
- From 20 Apr 2022 to the primary completion date, 22 Apr 2024
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who cannot be treated with upadacitinib as per SmPC or local prescription criteria.
- Prior treatment course with upadacitinib or the current upadacitinib treatment was started more than 1 week prior to enrollment.
Other
- Participant currently participating in any interventional study.
Who the study is looking for
- Diagnosis of moderate to severe active rheumatoid arthritis (RA) upon judgment of the treating physician.
- Upadacitinib prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies and upadacitinib treatment was started within 1 week before the enrollment.
- Physician decision on participant treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 234204 Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| Debreceni Egyetem-Klinikai Kozpont /ID# 246156 Coordinator of this site? Confirm its status | Debrecen | Hungary | Unknown status |
| Gyor-Moson-Sopron Varmegyei Petz Aladar Egyetemi Oktato Korhaz /ID# 234201 Coordinator of this site? Confirm its status | Győr | Hungary | Unknown status |
| Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz /ID# 239231 Coordinator of this site? Confirm its status | Gyula | Hungary | Unknown status |
| Kistarcsai Flor Ferenc Korhaz /ID# 234202 Coordinator of this site? Confirm its status | Kistarcsa | Hungary | Unknown status |
| BAZ Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz /ID# 246158 Coordinator of this site? Confirm its status | Miskolc | Hungary | Unknown status |
| Szegedi Tudományegyetem /ID# 244364 Coordinator of this site? Confirm its status | Szeged | Hungary | Unknown status |
| MÁV Kórház /ID# 246157 Coordinator of this site? Confirm its status | Szolnok | Hungary | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.