Fact CheckerSign in

NCT05332652Active, not recruiting

Establishing a Prognostic Model for Stroke Recovery

Neural Network Reorganization Associated With Upper Limb Motor Recovery in Stroke Patients- Establishing a Prognostic Model and Tailoring Neuromodulation for Rehabilitation

Source: ClinicalTrials.gov · Last updated 20 Feb 2026

Brief summary (registry, in English)

This main aim of the study is to investigate the changes in neurophysiological features after stroke, and its association with upper limb motor recovery, so as to establish a prognostic model for upper limb motor recovery after stroke. The investigators hypothesize that a combination of neurophysiological features measured by transcranial magnetic stimulation (TMS), high density electroencephalography (HD-EEG), functional magnetic resonance imaging (fMRI) and Diffusion Tensor Imaging (DTI) might be used as biomarkers to predict upper limb motor outcomes after stroke. The investigators also hypothesize that non-invasive brain stimulation strategies such as tDCS will more effectively improve motor outcomes as an adjunct to therapy, if tailored according to patient's predicted pattern of neural reorganization.

Status (registry)
Active, not recruiting
Study type
Interventional
Enrollment
41 (actual)
First submitted
13 Sept 2021
Start date
1 Sept 2020
Primary completion date
16 Jul 2026
Lead sponsor
National University Hospital, Singapore
Diseases
Stroke
NCT number
NCT05332652

What you commit to

  • Study type: Interventional
  • Participants enrolled: 41
  • From 1 Sept 2020 to the primary completion date, 16 Jul 2026
  • 2 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Criteria the registry did not label

  • Inclusion criteria for stroke patients:
    • 21-80 years old;
    • First ever stroke less than 6 weeks;
    • Moderate to severe upper limb impairment with Manual Muscle Testing (MMT) score on shoulder abduction plus finger extension (SAFE) \<5 within the first week post-stroke.
  • Inclusion criteria for healthy subjects:
    • Age 21-80 years old;
    • No known medical history.
  • Exclusion criteria for stroke patients:
    • Pregnancy;
    • Any metal implants inside the body that are contraindications of MRI scan;
    • cardiac pacemakers;
    • History of epilepsy;
    • Sensorimotor disturbance due to other causes other than stroke;
    • Claustrophobia;
    • Uncontrolled medical conditions including hypertension, diabetes mellitus and unstable angina;
    • Major depression and a history of psychotic disorders;
    • Terminal diagnosis with life expectancy \<=1 year.
  • Exclusion criteria for healthy subjects:
    • Pregnancy;
    • Any metal implants inside the body that are contraindications of MRI scan;
    • cardiac pacemakers;
    • Claustrophobia.

Age in the registry: 21 years to 80 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (2)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Alexandra Hospital
Coordinator of this site? Confirm its status		SingaporeSingaporeUnknown status
National University Hospital
Coordinator of this site? Confirm its status		SingaporeSingaporeUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.