NCT05333549CompletedPhase 2
Istradefylline for Parkinson Disease With Cognitive Impairment
Istradefylline for Parkinson Disease Cognitive Impairment
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
The purpose of this research study is to determine whether istradefylline improves cognition in individuals with Parkinson disease with cognitive impairment.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 15 (actual)
- First submitted
- 11 Apr 2022
- Start date
- 18 Jul 2022
- Primary completion date
- 9 Jun 2025
- Lead sponsor
- Virginia Commonwealth University
- Diseases
- Parkinson disease
- NCT number
- NCT05333549
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 15
- From 18 Jul 2022 to the primary completion date, 9 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Meet criteria for dementia with Lewy bodies, including dementia onset prior to or within 1 year of parkinsonism onset
Other illness
- Moderate or severe hepatic impairment
- dementia too severe to complete study measures or to adhere to medication schedule
Other
- Presence of troublesome dyskinesias
- Pregnancy or possibility of becoming pregnant during the study period.
Who the study is looking for
- Meet criteria for probable Parkinson disease dementia or PD-MCI (mild cognitive impairment)
- Age greater than 50
- Hoehn and Yahr stage \< 4 in "on" state
- Currently taking carbidopa/levodopa
- Antiparkinsonian medications stable for at least 4 weeks prior to baseline visit
- Cholinesterase inhibitor dose stable for 8 weeks prior to baseline visit
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Virginia Commonwealth University Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.