NCT05340881Recruiting
Systematic Light Exposure in Pediatric Brain Tumor Survivors
Systematic Light Exposure Intervention for Fatigue and Cognitive Efficiency in Pediatric Brain Tumor Survivors
Source: ClinicalTrials.gov · Last updated 18 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Children and adolescents treated for a brain tumor often experience fatigue and cognitive symptoms, such as slowed information processing and inattention. These symptoms may cause difficulty carrying out daily activities at home and at school. There are few well-researched, non-pharmacological interventions aimed at improving symptoms of fatigue and by extension cognitive symptoms. Systematic bright light exposure has been shown to improve symptoms of fatigue in adult survivors of cancer and children treated for some forms of cancer. This is a pilot/feasibility study and the first known study in children treated for a brain tumor. Findings from this study will be used to help plan a larger study to examine the effectiveness of this intervention and mechanisms of action. PRIMARY OBJECTIVE: 1. To evaluate feasibility and adherence in a study of systematic bright light exposure used to improve fatigue and cognitive efficiency in survivors of pediatric brain tumor, including rates of enrollment, adherence, and acceptability. SECONDARY OBJECTIVES: 2. To estimate the effect size of change in fatigue associated with bright light exposure. 3. To estimate the effect size of change in cognitive efficiency associated with bright light exposure.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 23 Mar 2022
- Start date
- 14 Oct 2022
- Primary completion date
- Jun 2026
- Lead sponsor
- Baylor College of Medicine
- Diseases
- Childhood cancers
- NCT number
- NCT05340881
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 14 Oct 2022 to the primary completion date, Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or previous (within 12 months) suicidal ideation or severe depression requiring immediate intervention
- Use of photosensitizing medications
- Current or previous use of light therapy
Other illness
- Diagnosis and/or treatment for secondary malignancy in the past 12 months
- Presence of photophobia or other eye diseases, seizures, and/or migraines
Who the study is looking for
- Diagnosed and treated for a brain tumor at Texas Children's Hospital
- Treated with either surgery only or surgery and proton beam radiation therapy
- Treated for tumors other than high-grade gliomas, brain stem gliomas, or atypical teratoid rhabdoid tumors given associated reduced survival rates
- Currently or previously enrolled in longitudinal studies of neurocognitive outcomes in survivors of pediatric brain tumor (Lisa Kahalley, PI; H-29026, H-35681, H-40804, H-40961, H-49380, H-26785, H-41705
- Ages 10-18 years
- At least 1 year post-diagnosis
- Endorsed mild to moderate symptoms of fatigue on the PROMIS
- Approval from Long-Term Survivorship provider
- Adequate vision for computerized tasks
- English-speaking
- Intelligence Quotient (IQ) above 70
Age in the registry: 10 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Texas Children's Hospital Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.