NCT05341986Active, not recruiting
Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation With an Electronic Clinical Decision Support Tool
Optimizing Stroke Prophylaxis of Acute Atrial Fibrillation With an Electronic Clinical Decision Support Tool: A Stepped-Wedge Cluster Randomized Trial Design
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
Atrial fibrillation (AF) is the most common arrhythmia in the world, with significant morbidity and mortality. With appropriate oral anticoagulation, the risk of stroke due to atrial fibrillation decreases by 64%. Although atrial fibrillation is commonly diagnosed and treated in the Emergency Department (ED), oral anticoagulation is significantly underprescribed. Underprescribing has been attributed to a lack of empowerment and deferral of prescribing to longitudinal care clinicians. Using a convergent parallel quantitative-qualitative design (mixed-methods), we propose a stepped-wedge cluster randomized trial design with the implementation of a clinical decision support (CDS) tool in adults with new-onset AF that are OAC-naïve and at significant risk for stroke. In parallel, we will use qualitative approaches to evaluate clinician facilitators and barriers to tool utilization as well as patient satisfaction and engagement with the tool.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 13 Apr 2022
- Start date
- Jan 2022
- Primary completion date
- Aug 2026
- Lead sponsor
- Oregon Health and Science University
- Diseases
- Stroke, Atrial fibrillation
- NCT number
- NCT05341986
What you commit to
- Study type: Interventional
- Planned participants: 36
- From Jan 2022 to the primary completion date, Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent brain, eye or spinal cord injury or surgery; OR
- Evidence of non-OAC naïve patient:
- OAC prescribed in the prior 3mo to index ED visit; OR
- Being managed by an anticoagulation clinic (ACC);
- Inclusion/Exclusion Criteria (Clinicians): All ED clinicians (board certified or eligible) interfacing with patients.
Other illness
- Valvular disease, pregnancy, large esophageal varices, thrombocytopenia, severe or uncontrolled bleeding, severe liver or kidney disease, major surgery within 72 hours; OR
- ED stroke, death or hospitalization at index visit; OR
Other
- Patient transferred from another hospital (to ensure availability of index ED visit data); OR
- Left against medical advice; OR
Who the study is looking for
- A diagnosis of atrial fibrillation or paroxysmal atrial fibrillation (ICD-10 I48.0, I48.1, I48.9) during an ED visit with start dates between 1/11/2022 and 08/30/2026 within the patient's age ≥18 years.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oregon Health & Science University (OHSU) Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.