NCT05351476Recruiting
Exercise Training and Fat Metabolism in Postmenopausal Women
Resistance Training Modulation of Fat Metabolism in Obese Postmenopausal Women
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 4 Apr 2022
- Start date
- 20 May 2022
- Primary completion date
- 30 Apr 2027
- Lead sponsor
- Florida State University
- Diseases
- Obesity
- NCT number
- NCT05351476
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 20 May 2022 to the primary completion date, 30 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking any medication affecting lipid metabolism
Other illness
- Type 1 or type 2 diabetes
- Medical problems in which exercise is contraindicated, such as chronic infections
- History of, or currently presentation with, cancer, cardiovascular or respiratory disease
- Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
- Smokers and those with diagnosed eating disorders
Other
- Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
- Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
- Uncontrolled thyroid dysfunction, liver or renal dysfunction
Who the study is looking for
- Women
- Postmenopausal (50-75 yrs.)
- Obese (BMI 30-50 kg/m2)
- Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
- Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
- Non-smokers
- No hormone replacement therapy for at least the past two years.
Age in the registry: 50 years to 75 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Florida State University Coordinator of this site? Confirm its status | Tallahassee | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.