NCT05355363Completed
Risk of Metachronous Findings After Detection of Serrated Lesions and High-grade Dysplasia With Surveillance Delay
Source: ClinicalTrials.gov · Last updated 18 Sept 2026
Brief summary (registry, in English)
The primary aim of this study is to determine the rate of total metachronous advanced neoplasia (TMAN) detection after index detection of serrated lesions (SL) \[sessile serrated polyps (SSPs), traditional serrated adenomas (TSAs)\], and metachronous high-risk adenoma (HRA) after index detection of high-grade dysplasia (HGD). We will use the database of patients diagnosed with SL or HGD at index colonoscopy with a delay in surveillance and determine the risk of advanced lesions (especially high-risk lesion and CRC detection) of these delayed colonoscopies. The aim is to determine the effects of breach of continuity of care in these patients.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 727 (actual)
- First submitted
- 4 Apr 2022
- Start date
- 27 Feb 2023
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
- Diseases
- Colorectal cancer
- NCT number
- NCT05355363
What you commit to
- Study type: Interventional
- Participants enrolled: 727
- From 27 Feb 2023 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 6\) Follow-up colonoscopy not yet due according to USMSTF guidelines. Patients with concomitant HRA and SL at index will be invited to participate if the index (or last) colonoscopy was performed more than 1 year ago. This is based on the high rates of HRA we identified in our retrospective study posing increased risks for these patients.
Other illness
- 1\) Patients with a diagnosis of inflammatory bowel disease;
- 2\) Hereditary CRC syndromes;
- 4\) Serrated polyposis syndrome;
Other
- 3\) CRC at index colonoscopy;
- 5\) Life expectancy too short to benefit from colonoscopy;
Who the study is looking for
- Patients 45-80 who underwent colonoscopy from 2009 to 2022 at the Montreal University Hospital Center (CHUM) with 1+ SL or HGD detected at index colonoscopy and lacking follow-up within or beyond the surveillance interval recommended by 2020 USMSTF guidelines.
Age in the registry: 45 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centre Hospitalier de l'Université de Montréal Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.