NCT05355389Recruiting
Cognitive-motor Telerehabilitation in MS
Cognitive-motor Telerehabilitation in Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 14 Apr 2022
- Start date
- 1 Sept 2022
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- Universitair Ziekenhuis Brussel
- Diseases
- Multiple sclerosis
- NCT number
- NCT05355389
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 1 Sept 2022 to the primary completion date, 31 Aug 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cognitive rehabilitation within six months before inclusion
- Inpatient multidisciplinary rehabilitation program within three months before inclusion or planned inpatient program during trial
- Start of or switch in immunomodulator treatment within three months before inclusion
Other illness
- Major psychiatric or medical disorder that could influence cognitive functions
Other
- Less than one month post-exacerbation
- Combined vision with optimal correction below 0.6 on Snellen Visual Acuity Test
- Unable or unwilling to undergo EEG or MRI
- Refusing informed consent
Who the study is looking for
- Clinically definite multiple sclerosis (revised McDonald criteria 2017)
- Expanded Disability Status Scale (EDSS) below 6.0
- Digit span backwards z-score between \[-3 and -0.5\] standard deviations below the median of the normative values
- Age between 18 and 65
- Able to safely perform motor rehabilitation in the home situation (assessed by rehabilitation physician and/or occupational or physiotherapist)
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universitair Ziekenhuis Brussel Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
| National MS Center Melsbroek Coordinator of this site? Confirm its status | Melsbroek | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.