NCT05356000Recruiting
GI Oxalate Absorption
Determine the Contribution of Paracellular GI Oxalate Absorption in Obese and Roux-en-Y Gastric Bypass Kidney Stone Patients
Source: ClinicalTrials.gov · Last updated 19 Aug 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 26 Apr 2022
- Start date
- 25 Jan 2023
- Primary completion date
- 2 Jun 2026
- Lead sponsor
- University of Chicago
- Diseases
- Obesity
- NCT number
- NCT05356000
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 25 Jan 2023 to the primary completion date, 2 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of colon resection (partial or complete)
- History of duodenal switch bowel surgery
- History of ileal-jejunal bypass surgery
- History of primarily uric acid, cysteine, or struvite stones
- Obese and non-obese stone formers:
- History of bowel surgery
- History of colon resection
- History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
- History of primarily uric acid, cysteine, or struvite stones
Other
- Post-Roux-en-Y gastric bypass stone formers:
Who the study is looking for
- Post-Roux-en-Y gastric bypass stone formers:
- Age 18-70
- Previous history of Roux-en-Y gastric bypass
- History of at least one calcium-based kidney stone after surgery
- Pre-protocol urine oxalate above the lab normal range (50mg/day)
- Obese stone formers:
- Age 18-70
- Body mass index (BMI) \>=30kg/m2
- History of at least one calcium-based kidney stone
- Pre-protocol urine oxalate above the lab normal range (50mg/day)
- Non-obese stone formers:
- Age 18-70, BMI between 18.5-29.9 kg/m2
- History of at least one calcium-based kidney stone
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Chicago Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.