NCT05357690CompletedPhase 2/3
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation
Stellate Ganglion Blockade for the Prevention of Atrial Fibrillation After Cardiac Surgery: A Randomized Placebo-Controlled Trial
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to test if a nerve block procedure called a stellate ganglion block can help decrease the chance of atrial fibrillation after surgery. Atrial fibrillation is the abnormal, fast beating of the upper chambers of the heart. Stellate ganglion blockade has shown to decrease other types of abnormal heart rhythms as well as decrease the chance of atrial fibrillation.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 200 (actual)
- First submitted
- 27 Apr 2022
- Start date
- 19 Apr 2023
- Primary completion date
- 8 Jun 2026
- Lead sponsor
- Mayo Clinic
- Diseases
- Atrial fibrillation
- NCT number
- NCT05357690
What you commit to
- Study type: Interventional · Phase 2/3
- Participants enrolled: 200
- From 19 Apr 2023 to the primary completion date, 8 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pre-operative immunosuppressive medication use (including steroid use).
- Pre-operative anti-arrhythmic medication use (aside from beta-blockers).
Other illness
- Patients with a history of permanent atrial fibrillation, left or right ventricular assist device implantation or explantation.
- Patients with active infection or sepsis.
- Patients with Immunodeficiency syndrome.
- Patients with known neurologic disorder.
Other
- Patients with procedures not requiring cardiopulmonary bypass.
- Patients with procedures requiring deep hypothermic circulatory arrest.
- Patients requiring left internal jugular central line placement.
- Performance of Maze procedures or left atrial appendage ligation procedures will not exclude patients from potential enrollment as atrial fibrillation still occurs postoperatively while the scarring from the Maze procedure forms.
Who the study is looking for
- Patient presenting for cardiac surgery at the Mayo Clinic in Rochester, Minnesota.
- Patients scheduled to undergo mitral or aortic valve surgery with or without coronary artery bypass grafting.
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.