NCT05359887Active, not recruiting
PET-study on the Role of the Reward System in Weight Loss After Bariatric Surgery
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
Bariatric surgery (BS) is currently the most effective treatment in severe obesity. However, a considerable percentage of patients undergoing BS fail to lose sufficient weight or regain weight after initial weight loss during long-term follow-up, which may be attributed to personality traits and pathological eating behaviour. Previous positron emission tomography (PET) studies have shown reduced dopamine D2 receptor availability in obese patients and upregulation of this availability following successful BS in the brain's reward system. Dopamine D2 receptor availability in patients with unsuccessful BS has not been investigated to date.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 12 Apr 2022
- Start date
- 1 Dec 2022
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- University Medical Center Groningen
- Diseases
- Obesity
- NCT number
- NCT05359887
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Dec 2022 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The use of drugs that bind to dopamine D2/3 receptors, including various classes of antipsychotics and antidepressants
- Alcohol consumption 24h prior to PET scanning
- Smoking or other forms of nicotine intake 12 hours prior to PET scanning
- Use of anorectic drugs in the last 6 months
Other illness
- Presence of a DSM-IV axis 1 disorder
- History of stroke, brain tumor, Parkinson's Disease or dementia
- History of head trauma with loss of consciousness
- Medication for Diabetes Mellitus
Other
- Alcohol or substance abuse in the last 6 months
- Current pregnancy
- Claustrophobia
- The presence of implanted metal objects of the type which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (such as certain implanted devices, shrapnel, ocular metal shavings)
- Patients with a bodyweight \> 200kg will be excluded to ensure the maximum load of the camera bed of the PET-scanner (227 kg) is not exceeded.
Who the study is looking for
- Bariatric surgery 24-36 months prior to the study
- Adult (over 18y old)
- Mentally capable to understand the consequences of the procedure and make his or her own choice without coercion
- Able to undergo PET and MRI, according to the investigator's assessment
- Native speaking
- Able to participate in follow-up
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| MCL Coordinator of this site? Confirm its status | Leeuwarden | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.