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NCT05361434Completed

A Study of the Effectiveness of Cabozantinib in Combination With Nivolumab as First-line Treatment of Advanced Renal Cell Carcinoma (aRCC) in Adults

A Prospective Observational International Study of Cabozantinib Tablets in Combination With Nivolumab as First-line Treatment of Advanced Renal Cell Carcinoma in Adults

Source: ClinicalTrials.gov · Last updated 1 Jun 2026

Brief summary (registry, in English)

The purpose of this study is to collect data to describe the safety and effectiveness of cabozantinib and nivolumab in combination as a first-line treatment in adults with aRCC with clear cell-component, according to real-world clinical practice. The decision to prescribe cabozantinib and nivolumab in combination will be made prior to, and independently from, the decision to enrol the participant in study.

Status (registry)
Completed
Study type
Observational
Enrollment
311 (actual)
First submitted
29 Apr 2022
Start date
26 Sept 2022
Primary completion date
20 Oct 2025
Lead sponsor
Ipsen
NCT number
NCT05361434

What you commit to

  • Study type: Observational
  • Participants enrolled: 311
  • From 26 Sept 2022 to the primary completion date, 20 Oct 2025
  • 66 sites in 8 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • History of allergy or hypersensitivity to Cabometyx® or Opdivo® components.

Other

  • Current participation in an investigational program with any intervention which could possibly interfere the treatment and impact this study;

Who the study is looking for

  • Participants with diagnosis of aRCC with clear-cell component
  • Participants with no prior systemic treatment for aRCC with clear-cell component;
  • Physician-initiated decision to treat with cabozantinib and nivolumab in combination (prior to study enrolment), according to Cabometyx® and Opdivo® approved local labels;

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (66)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
CHU St Pierre & Brugmann
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BrusselsBelgiumUnknown status
JESSA Ziekenhuis
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HasseltBelgiumUnknown status
CHU Namur Mont-Godinne
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YvoirBelgiumUnknown status
Centre Hospitalier Universitaire (CHU) de Angers
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AngersFranceUnknown status
Hopital de Mercy- CHR Metz Thionville
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Ars-LaquenexyFranceUnknown status
Institut Ste Catherine - Institut du Cancer Avignon Provence
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AvignonFranceUnknown status
Centre Hospitalier Régional Universitaire de Besançon - Jean Minjoz
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BesançonFranceUnknown status
ICONE
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BezannesFranceUnknown status
Institut Bergonie
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BordeauxFranceUnknown status
Groupe Hospitalier Saint-André (Bordeaux)
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BordeauxFranceUnknown status
Centre Hospitalier de Boulogne-Sur-Mer
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Boulogne-sur-MerFranceUnknown status
Centre hospitalier Fleyriat
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Bourg-en-BresseFranceUnknown status
Centre Finisterien de Radiotherapie et d'Oncologie
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BrestFranceUnknown status
Centre d'Urologie Site Médipole - Centre Catalan d'Urologie
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CabestanyFranceUnknown status
Centre de lutte contre le cancer Jean Perrin
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Clermont-FerrandFranceUnknown status
Centre Hospitalier Universitaire de Clermont Ferrand - Gabriel Montpied
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Clermont-FerrandFranceUnknown status
Centre Hospitalier Universitaire (CHU) Henri Mondor
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CréteilFranceUnknown status
Institut de Cancérologie de Bourgogne
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DijonFranceUnknown status
Centre Georges François Leclerc
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DijonFranceUnknown status
Centre Hospitalier Annecy Genevois
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ÉpagnyFranceUnknown status
Centre Hospitalier intercommunal Saint Raphaël Frejus
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FréjusFranceUnknown status
Groupe Hospitalier de la Rochelle Re-Aunis
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La RochelleFranceUnknown status
Centre Hospitalier Départemental Vendée
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La Roche-sur-YonFranceUnknown status
Centre Hospitalier Universitaire Grenoble Alpes
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La TroncheFranceUnknown status
Hôpital Privé Le Bois
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LilleFranceUnknown status
Hôpital Privé Jean Mermoz
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LyonFranceUnknown status
Centre Hospitalier Universitaire (CHU) de Nantes - Hôtel-Dieu
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NantesFranceUnknown status
Centre Hospitalier Regional d Orleans
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OrléansFranceUnknown status
Hôpital Européen Georges Pompidou (HEGP)
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ParisFranceUnknown status
Centre Hospitalier Tenon
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ParisFranceUnknown status
Hopital Bichat -Claud Bernard
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ParisFranceUnknown status
Hopital Pitie-Salpetriere
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ParisFranceUnknown status
Centre Hospitalier Universitaire (CHU) de Poitiers
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PoitiersFranceUnknown status
Clinique Mathilde Oncologie médicale
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RouenFranceUnknown status
CHU Charles Nicolle
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RouenFranceUnknown status
Centre d'Oncologie de l'Estuaire
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Saint-NazaireFranceUnknown status
ICANS - Institut de cancérologie Strasbourg Europe
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StrasbourgFranceUnknown status
Hospital Foch - Oncology Service
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SuresnesFranceUnknown status
Hospital Foch - Urology Service
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SuresnesFranceUnknown status
Centre Hospitalier Régional Universitaire de (CHRU) de Tours - Hôpital Bretonneau
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ToursFranceUnknown status
CH Dentellières
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ValenciennesFranceUnknown status
Institut de Cancérologie de Lorraine Alexis Vautrin
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Vandœuvre-lès-NancyFranceUnknown status
Belfast City Hospital
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BelfastUnited KingdomUnknown status
Edinburgh Cancer Centre, Western General Hospital
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EdinburghUnited KingdomUnknown status
General Hospital of Athens - Alexandra
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AthensGreeceUnknown status
Henry Dunant Hospital
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AthensGreeceUnknown status
ATTIKO University Hospital
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ChaïdáriGreeceUnknown status
Papageorgiou General Hosp of Thessaloniki
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ThessalonikiGreeceUnknown status
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori", IRCCS - Oncologia
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MeldolaItalyUnknown status
Fondazione IRCCS - Istituto Nazionale dei Tumori
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MilanItalyUnknown status
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
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NaplesItalyUnknown status
Aou San Luigi Gonzaga
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OrbassanoItalyUnknown status
IOV - Istituto Oncologico Veneto - IRCCS - Ospedale Busonera
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PadovaItalyUnknown status
P.O. "Santa Maria delle Grazie" - ASL Napoli 2 Nord
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PozzuoliItalyUnknown status
Ospedale Generale Provincial
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Province of MacerataItalyUnknown status
Ospedale Santa Maria delle Croci di Ravenna
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RavennaItalyUnknown status
Ospedale San Camillo Forlanini
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RomaItalyUnknown status
PU A. Gemelli, Universita Cattolica del Sacro Cuore
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RomaItalyUnknown status
Policlinico Universitario Campus Biomedico
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RomaItalyUnknown status
Chonnam National University Hwasun Hospital
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JeongnamSouth KoreaUnknown status
Seoul St. Mary's Hospital
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SeoulSouth KoreaUnknown status
Samsung Medical Center
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SeoulSouth KoreaUnknown status
Severance Hospital, Yonsei University Health System
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SeoulSouth KoreaUnknown status
Akershus universitetssykehus
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LørenskogNorwayUnknown status
King Abdulaziz Medical City - Jeddah
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JeddahSaudi ArabiaUnknown status
King Abdulaziz Medical City- Riyadh
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RiyadhSaudi ArabiaUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.