NCT05366387Completed
Effect of Intrapulmonary Percussion Ventilation on Deposition of Inhaled Aerosols in Idiopathic Pulmonary Fibrosis
Source: ClinicalTrials.gov · Last updated 1 Dec 2025
Brief summary (registry, in English)
This protocol aims to evaluate the feasibility and benefit of Intrapulmonary Percussive Ventilation (IPV) to improve deposition of inhaled radiolabelled aerosols in fibrotic lung regions of patients with Idiopathic Pulmonary Fibrosis (IPF). Phase 1 of the protocol aims to identify the highest IPV pressure that is tolerated by individual patients. Secondary endpoints explore safety of IPV in IPF patients. Phase 2 of the protocol is a crossover randomized trial where patients will inhale 99mTc-labelled DiethyleneTriamine PentaAcetate (DTPA) aerosols with or without IPV. Aerosol deposition in HRCT-defined fibrotic regions of interest (ROI) is described by Single Photon Emission Computed Tomography (SPECT).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 9 (actual)
- First submitted
- 25 Mar 2022
- Start date
- 23 Nov 2022
- Primary completion date
- 12 Feb 2025
- Lead sponsor
- University Hospital, Tours
- Diseases
- Idiopathic pulmonary fibrosis
- NCT number
- NCT05366387
What you commit to
- Study type: Interventional
- Participants enrolled: 9
- From 23 Nov 2022 to the primary completion date, 12 Feb 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 24h/24 oxygen therapy
Other illness
- Other chronic lung disease
- History of congestive heart failure
- History of IPF exacerbation
- History of lung cancer
- Any acute lung disease
- Any potentially transmissible lung infection
- History of pneumothorax or pneumomediastinum
Other
- Airflow obstruction (FEV1/FVC\<0.7)
- Chronic cough precluding aerosol delivery and radioprotection
- Claustrophobia
- Current or possible pregnancy and breastfeeding
- Contra-indications to IPV : Emphysema, recent barotrauma, pneumothorax, pneumomediastinum
- Patient unable to hold a mouthpiece tightly
- Patient under legal protection (guardianship, curatorship)
- Contraindication to the administration of Technescan DTPA
Who the study is looking for
- Diagnosis of IPF according to 2018 ATS/ERS/JRS/ALAT guidelines
- Affiliation to health insurance
- Signed informed consent
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pulmonology Department, University Hospital, Tours Coordinator of this site? Confirm its status | Tours | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.