NCT05369182Active, not recruiting
Multicenter Registry of Coronary Flow-Derived Indexes for Coronary Microvascular Disease (Multicenter FLOW-CMD Registry)
Prospective Registry of Coronary Flow-Derived Indexes in Patients With Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 12 Feb 2026
Brief summary (registry, in English)
Multicenter FLOW-CMD registry is a prospective, multi-center, registry study. The aim of the study is to evaluate prognostic implications of coronary microvascular disease (CMD) in patients with ischemic heart disease (IHD) undergoing revascularization decision using FFR or other non-hyperemic pressure ratios.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1003 (actual)
- First submitted
- 23 Apr 2022
- Start date
- 22 Apr 2022
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Samsung Medical Center
- Diseases
- Coronary artery disease
- NCT number
- NCT05369182
What you commit to
- Study type: Observational
- Participants enrolled: 1003
- From 22 Apr 2022 to the primary completion date, 31 Dec 2025
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Cardiogenic shock (systolic blood pressure \<90mmHg or requiring inotropics to maintain blood pressure \>90mmHg) or cardiac arrest
- Non-cardiac co-morbid conditions are present with life expectancy \<2 year (per site investigator's medical judgment).
Other
- Inability to undergo physiologic assessment (CFR, IMR, and FFR)
- Pregnant or lactating women
Who the study is looking for
- Subject must be ≥18 years
- Patients suspected with IHD
- Patients undergoing physiologic assessment (CFR, IMR, and FFR) for evaluation of severity of CAD
- Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic or imaging evaluation and he/she or his/her legally authorized representative provides written informed consent to any study related procedure.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chosun University Hospital Coordinator of this site? Confirm its status | Gwangju | South Korea | Unknown status |
| Chonnam National University Hospital Coordinator of this site? Confirm its status | Gwangju | South Korea | Unknown status |
| Gyeongsang National University Hospital Coordinator of this site? Confirm its status | Jinju | South Korea | Unknown status |
| Seoul National University Bundang Hospital Coordinator of this site? Confirm its status | Seongnam | South Korea | Unknown status |
| Seoul National University Boramae Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Seoul St. Mary's Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
Related publications
- Microvascular resistance reserve and cardiovascular outcomes: the FLOW-CMD registry.Eur Heart J · 2026 · PMID 42661450
- Coronary microvascular dysfunction and cardiovascular outcomes (Multicenter FLOW-CMD Registry): a prospective, multicentre cohort study in South Korea.Lancet · 2026 · PMID 42167298
This page is information, not medical advice. Discuss any trial with your doctor.