Prognosis and Antiplatelet Strategies for Patients With PCI and High Bleeding Risk:A Study Protocol

Prior treatment

• Patients who could not be followed up (including previously reserved phone changes, etc.) to obtain MACE events.

Other illness

• Patients who were already bleeding at the time of baseline inclusion

• PCI patients \>18 years of age and meeting 1 major criterion or 2 minor criteria of the ARC-HBR The ARC-HBR major criteria included:
• long-term use of oral anticoagulants;
• severe or end-stage chronic kidney disease \[eGFR \<30 ml/(min\*1.73m2 )\];
• hemoglobin \<11 g/dl, spontaneous bleeding requiring hospitalization or transfusion within the past 6 months or at any time;
• chronic bleeding constitutional;
• cirrhosis with portal hypertension spontaneous bleeding requiring hospitalization or transfusion within the past 6 months or at any time;
• moderate to severe baseline thrombocytopenia (platelets \<100×10\^9/L); chronic bleeding constitutional;
• cirrhosis with portal hypertension;
• active malignancy within the past 12 months (excluding non-melanoma skin cancer);
• previous spontaneous brain hemorrhage (at any time);
• traumatic brain hemorrhage within the past 12 months;
• within the past 6 months moderate or severe ischemic stroke within the past 6 months;
• the presence of cerebral arteriovenous malformation;
• recent major surgery or major trauma within 30 days prior to PCI;
• and major non-delayable surgery during DAPT.
  • Secondary criteria included:
• age ≥75 years;
• moderate chronic kidney disease \[30 ml/(min\*1.73m2 ) ≤ eGFR ≤ 59 ml/(min\*1.73m2 )\];
• 11 g/dl ≤ hemoglobin \< 13 g/dl in men and 11 g/dl ≤ hemoglobin \< 12 g/dl in women; - spontaneous bleeding requiring hospitalization or blood transfusion in the past 6 months to 12 months;
• long-term use of oral NSAIDs or steroids
• Ischemic stroke of any duration not covered by the primary criteria.