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NCT05378126Completed

Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis

Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis

Source: ClinicalTrials.gov · Last updated 1 May 2026

Brief summary (registry, in English)

Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per 100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis. Brain MRI can detect the presence of recent ischemic lesions and asymptomatic microbleeds. Preoperative brain imaging is part of the recommended assessment in the management of IEs, but the type of imaging and sequences are not codified and the impact of cerebral and vascular imaging findings on the therapeutic decision remains uncertain. The level of evidence of the recommendations remains low, especially for complicated IEs of stroke. There is very little neurological clinical data on patients with IEs. Similarly, neurologists do not systematically participate in multidisciplinary meetings during the management of an IE. It therefore seems interesting to carry out a neurological cohort of this population and to evaluate what would be the contribution of vascular neurologists in the management of infectious endocarditis.

Status (registry)
Completed
Study type
Interventional
Enrollment
29 (actual)
First submitted
11 May 2022
Start date
6 Apr 2023
Primary completion date
22 May 2025
Lead sponsor
Hospices Civils de Lyon
Diseases
Stroke
NCT number
NCT05378126

What you commit to

  • Study type: Interventional
  • Participants enrolled: 29
  • From 6 Apr 2023 to the primary completion date, 22 May 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Age

  • Pregnant or women of childbearing age who were not using contraception (oral diagnosis),

Other

  • Hospital admission due to neurovascular emergency
  • MRI contraindications
  • Patient without health coverage,
  • Patient under legal protection.

Who the study is looking for

  • Adult patients
  • Certain infectious endocarditis according to Dukes Criteria
  • Signed informed consent

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Stroke Unit, Pierre Wertheimer hospital, GHE Hospices Civils de Lyon
Coordinator of this site? Confirm its status
BronFranceUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.