NCT05378126Completed
Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per 100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis. Brain MRI can detect the presence of recent ischemic lesions and asymptomatic microbleeds. Preoperative brain imaging is part of the recommended assessment in the management of IEs, but the type of imaging and sequences are not codified and the impact of cerebral and vascular imaging findings on the therapeutic decision remains uncertain. The level of evidence of the recommendations remains low, especially for complicated IEs of stroke. There is very little neurological clinical data on patients with IEs. Similarly, neurologists do not systematically participate in multidisciplinary meetings during the management of an IE. It therefore seems interesting to carry out a neurological cohort of this population and to evaluate what would be the contribution of vascular neurologists in the management of infectious endocarditis.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 29 (actual)
- First submitted
- 11 May 2022
- Start date
- 6 Apr 2023
- Primary completion date
- 22 May 2025
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Stroke
- NCT number
- NCT05378126
What you commit to
- Study type: Interventional
- Participants enrolled: 29
- From 6 Apr 2023 to the primary completion date, 22 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- Pregnant or women of childbearing age who were not using contraception (oral diagnosis),
Other
- Hospital admission due to neurovascular emergency
- MRI contraindications
- Patient without health coverage,
- Patient under legal protection.
Who the study is looking for
- Adult patients
- Certain infectious endocarditis according to Dukes Criteria
- Signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stroke Unit, Pierre Wertheimer hospital, GHE Hospices Civils de Lyon Coordinator of this site? Confirm its status | Bron | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.