Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.

Other illness

• Exacerbation of chronic diseases, requiring a change in patient management tactics and preventing his or her further participation in the study.

Other

• Refusal to further participation in the study;
• Acute psychotic reactions arising in the process of the study;

• Written informed consent to participate in the study;
• Age 40 and over;
• Male and female;
• One or more cardiovascular pathologies in the anamnesis:
  • a reliably confirmed diagnosis of hypertension, stage I-III (the diagnosis was made in accordance with the National Clinical Guidelines - 2019);
  • stable angina pectoris I-III functional class, confirmed by complaints, anamnesis and physical examination and with the help of diagnostic tests (bicycle ergometry or daily electrocardiography monitoring);
  • confirmed diagnosis of arrhythmias and conduction disorders based on electrocardiography data and 24-hour Holter monitoring (premature depolarization, supraventricular tachycardia, atrial fibrillation, sick sinus syndrome, atrioventricular block I-II, bundle branch blocks);
  • chronic heart failure stage I-IIB, I-III functional class (New York Heart Association Functional Classification), confirmed by the presence of clinical signs and at least one of two criteria: myocardial dysfunction of left ventricle or / and an increase in the level of the N-terminal fragment of brain natriuretic peptide over 125 pg / ml;
  • the presence of signs of systolic or diastolic dysfunction of the left ventricle according to echocardiography.
• COVID-19 infection confirmed by laboratory tests (polymerase chain reaction testing, enzyme-linked immunosorbent assay (positive result at least 1 time) with a CT degree of 3 or higher.
  • Non-inclusion criteria:
• Acute infectious diseases, tuberculosis;
• Chronic somatic diseases in the acute stage;
• Congenital anomalies of the heart and large vessels;
• Valvular heart defects (congenital and acquired);
• Severe atherosclerosis of the lower extremities'vessels (chronic ischemia of the lower extremities,stage 3-4);
• Acute decompensated heart failure (II-IV class according to Killip classification);
• Chronic heart failure IV functional class (New York Heart Association Functional Classification classification);
• Secondary arterial hypertension;
• Acute coronary syndrome within 4 weeks before the start of the study;
• Life-threatening rhythm and conduction disturbances;
• Bronchial asthma with the development of respiratory failure II-III degree;
• Acute cerebrovascular accident within the last 4 months;
• Chronic kidney disease (glomerular filtration rate\<30 ml / min / 1.73 m2 via CKD-EPI (chronic kidney disease epidemiology collaboration) formula);
• Pregnancy;
• Mental illness (severe dementia, schizophrenia, severe depression, manic-depressive psychosis);
• Oncology, diagnosed within a year or receiving a course of radiation / chemotherapy for cancer at the present time;
• Severe cognitive impairment (MOS) and clinically significant anxiety and / or depression (HADS) interfering with observation;
• Individual intolerance to oxygen deficiency.