NCT05381844Completed
Quantification of Antisense HIV RNA in Patients
Quantification of Antisense VIH-1 Transcripts and Comparison in Different Groups of Patients
Source: ClinicalTrials.gov · Last updated 12 Mar 2025
Brief summary (registry, in English)
The objective of this study is to quantify the expression levels of the HIV-1 unspliced sense transcript and of total HIV-1 antisense transcripts in PBMCs of HIV-1-infected persons, either still untreated or virologically controlled on treatment, and to investigate their correlations with the HIV reservoir as assessed by the quantification of total and integrated HIV-1 DNA.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 60 (actual)
- First submitted
- 16 May 2022
- Start date
- 20 Oct 2022
- Primary completion date
- 18 Oct 2024
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Diseases
- HIV
- NCT number
- NCT05381844
What you commit to
- Study type: Observational
- Participants enrolled: 60
- From 20 Oct 2022 to the primary completion date, 18 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- participation in a trial testing a medication in the 3 months preceding blood sampling
Other illness
- ongoing HIV primary infection
- coinfection with HIV-2 or HTLV-1/2
- ongoing AIDS-defining clinical condition
- ongoing infectious disease of any type
Other
- ongoing immunosuppressive treatment
- incompetent adults, persons under the protection of a conservator, tutor or guardian
- pregnant or lactating woman
Who the study is looking for
- HIV-1 infection
- ability to understand the objectives and protocols of the research and to sign the informed consent
- \* group 1 : treatment-naive patients with a detectable HIV-1 viral load
- Have not received any antiretroviral treatment
- At the chronic stage as determined during the clinical examination and confirmed by a western blot complete HIV antigens ("env" bands (gp 120 and 160). + "gag" and "pol" bands) with the presence of p31+
- \*Group 2: patients with chronic HIV-1 infection on antiretroviral therapy efficient
- Have been on antiretroviral therapy for less than a year
- With a plasma HIV RNA \< 50 copies/mL of blood for at least 6 months
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jean-Paul VIARD Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.