NCT05382052Active, not recruiting
Study of ctDNA as Prognostic Factor on Resectable Stage IIIA NSCLC Patients Treated With Neoadjuvant Treatment
Source: ClinicalTrials.gov · Last updated 19 Nov 2025
Brief summary (registry, in English)
This is an observational, prospective, multicentre and nationwide study. The study enroll resectable stage IIIA non-small cell lung cancer patients that are going to receive neoadjuvant treatment in real world. The primary objective of this study is evaluating whether there is a significant association between ctDNA clearance (no detection of ctDNA) after neoadjuvant treatment and before surgery and progression free survival.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 16 May 2022
- Start date
- 17 Jun 2022
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- Fundación GECP
- Diseases
- Lung cancer
- NCT number
- NCT05382052
What you commit to
- Study type: Observational
- Planned participants: 100
- From 17 Jun 2022 to the primary completion date, 30 Dec 2026
- 20 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 3\. Any medical, mental, or psychological condition which in the opinion of the investigator would not permit the patient to complete the study or understand the patient information.
Other
- 1\. Patients who refuse to sign and date an IRB/IEC-approved written informed consent form.
- 2\. No possibility of venipuncture
Who the study is looking for
- 1\. Previously untreated patients with histologically- or cytologically- documented NSCLC who present stage IIIA disease (according to 8th version of the International Association for the Study of Lung Cancer Staging Manual in Thoracic Oncology) and also, potentially resectable locally advanced NSCLC patients' stage IIIB with T3N2 disease according to 8th edition can be included.
- 2\. Tumor should be considered resectable before study entry by a multidisciplinary team
- 3\. ECOG 0-1
- 4\. Age ≥ 18 years at time of study entry
- 5\. Patients that are going to be treated with neoadjuvant treatment before surgery
- 6\. Patient capable of proper therapeutic compliance and accessible for correct follow-up
- 7\. Patients must have signed, dated and IRB/EC-approved written informed consent form in accordance with regulatory and institutional guidelines. This must be obtained before the performance of any protocol-related procedures that are not part of normal subject care.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario de A Coruna Coordinator of this site? Confirm its status | A Coruña | Spain | Unknown status |
| Hospital General Universitario de Alicante Coordinator of this site? Confirm its status | Alicante | Spain | Unknown status |
| Hospital Germans Trias i Pujol Coordinator of this site? Confirm its status | Badalona | Spain | Unknown status |
| Hospital Universitari Quiron Dexeus Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Hospital De Basurto Coordinator of this site? Confirm its status | Bilbao | Spain | Unknown status |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Unknown status |
| ICO Girona, Hospital Josep Trueta Coordinator of this site? Confirm its status | Girona | Spain | Unknown status |
| Hospital Universitario de Jaén Coordinator of this site? Confirm its status | Jaén | Spain | Unknown status |
| Hospital Universitario Lucus Augusti Coordinator of this site? Confirm its status | Lugo | Spain | Unknown status |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Clínico San Carlos Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Universitario Fundación Jiménez Díaz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
| Hospital Universitario Puerta de Hierro Coordinator of this site? Confirm its status | Majadahonda | Spain | Unknown status |
| Hospital Universitario Regional de Málaga Coordinator of this site? Confirm its status | Málaga | Spain | Unknown status |
| Hospital Universitari Son Llatzer Coordinator of this site? Confirm its status | Palma de Mallorca | Spain | Unknown status |
| Complejo Hospitalario de Navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Unknown status |
| Hospital Universitario la Fe Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| Hospital Clínico de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
| Hospital Clínico Universitario de Valladolid Coordinator of this site? Confirm its status | Valladolid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.