PET/MRI in Endometrial Cancer

Prior treatment

• If research-related radiation exposure exceeds current Radiology Department guidelines (i.e., 50 mSv in the prior 12 months)
• Perioperative liver transplantation period

Other illness

• Has Electrical implants, such as cardiac pacemakers or perfusion pumps
• Has Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, prosthetic heart valves that are not compatible with the gradient maps of our scanners, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, or steel implants not compatible with a 3 Tesla MR.
• A history of chronic severe renal insufficiency (glomerular filtration rate <30 mL/min/1.73m2)

Lab values

• Is actively anticipating being pregnant or breastfeeding (a negative STAT quantitative serum hCG pregnancy test is required on the day of the scan before the subject can participate)

Age

• Subjects less than 18 years of age or greater than 85 years of age

Other

• Weight greater than 300lbs (the PET/MRI table weight limit) or BMI > 33
• Suffers from claustrophobia
• Is unable to lie comfortably on a bed inside the PET/MRI bore as assessed by physical examination and medical history (e.g., back pain, arthritis)
• Subject is under the direct professional supervision of the principal investigator

• Women aged 18-85 years old with an endometrial biopsy-confirmed diagnosis of either grade 3 endometrioid, serous, carcinosarcoma, undifferentiated or mixed cell carcinoma
• Must have presumed stage I disease, i.e., no symptoms suggesting disease outside of the uterus (weight loss, early satiety, bloating, changes in bowel movement, etc.)
• Planning to undergo cytoreductive surgery with a Gynecologic oncologist employed by Massachusetts General Hospital
• No previous history of chronic severe renal insufficiency and a glomerular filtration rate of >30 mL/min/1.73m2. If the patient has a history of acute renal failure but their GFR as recovered to above 30,