NCT05390580Completed
Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct
Source: ClinicalTrials.gov · Last updated 31 Oct 2025
Brief summary (registry, in English)
This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 5 May 2022
- Start date
- 26 Sept 2022
- Primary completion date
- 23 Aug 2024
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Stroke
- NCT number
- NCT05390580
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 26 Sept 2022 to the primary completion date, 23 Aug 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Chronic or severe infection
- patients' undergoing active cancer or immunosuppressive/modulating therapy
- patients with sustained bradycardia on arrival with a heart rate \<50 beats per minute.
Age
- \<18 years old
Other
- patients with presumed chronic large vessel occlusions
- NIHSS\<6
- pre-morbid modified Rankin score (mRS) \>2
- unable to initiate treatment under 36 hours from symptom discovery
- life expectancy \<3 months
Who the study is looking for
- Adult patients who present with acute ischemic strokes due to large vessel occlusions
Age in the registry: 18 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University in St. Louis, School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
Related publications
- Neurofilament light chain dynamics following ischemic stroke and their modulation by transauricular vagus nerve stimulation.Sci Rep · 2026 · PMID 42675092
- Transcutaneous Auricular Vagus Nerve Stimulation Reduces Inflammatory Biomarkers after Large Vessel Occlusion Stroke: Results of a Prospective Randomized Open-Label Blinded Endpoint Trial.Transl Stroke Res · 2025 · PMID 41428140
This page is information, not medical advice. Discuss any trial with your doctor.