NCT05395598Recruiting
Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Predicting Moderate Thoracic Aortic Aneurysm Evolution: a Longitudinal Study of Systemic Factors in Patients Free of Connective Tissue Disease. .
Source: ClinicalTrials.gov · Last updated 15 May 2026
Brief summary (registry, in English)
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm. Different factors are supposed to increase the risk of aortic enlargement as high blood pressure and sleep disorder breathing. The modality of imaging and clinical follow-up are well defined. In this prospective observational study, the aim to assess the incidence of of major complications during follow-up in a population of patients with a small or moderate thoracic aneurysm. The study will also try to identify systemic factors influencing aneurysm evolution.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 320 (estimated)
- First submitted
- 24 May 2022
- Start date
- 18 Apr 2024
- Primary completion date
- 18 Apr 2031
- Lead sponsor
- University Hospital, Lille
- Diseases
- High blood pressure
- NCT number
- NCT05395598
What you commit to
- Study type: Observational
- Planned participants: 320
- From 18 Apr 2024 to the primary completion date, 18 Apr 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal or family history of genetically documented elastic tissue disease or patient meeting the GAND clinical criteria suggestive of Marfan disease
- High-grade mitra-aortic valve disease, even if asymptomatic
- Unbalanced hypertension ≥ 180/110 mmHg
- History of aortic surgery or endovascular intervention and history of type B aortic dissection of medical treatment
Lab values
- Renal insufficiency on dialysis, or GFR\< 30 ml/mn (CKD-EPI)
Other
- Presence of comorbidities or pathology with a prognosis of less than 1 year
- Aneurysm (regardless of thoracic or abdominal location) ≥ 50 mm
- Aneurysm (regardless of thoracic or abdominal location) with documented progression of more than 5 mm over one year
Who the study is looking for
- Documentation of an aortic root aneurysm \> 40 mm
- Agreement to participate to a longitudinal study and available for a 5 years follow-up
Age in the registry: 45 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Lille Coordinator of this site? Confirm its status | Lille | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.