NCT05397405Recruiting
Improving Blood Lipid Management in Symptomatic Intracranial Atherosclerotic Stenosis on Clinical Outcome
A Prospective Observational Study on the Effect of Improving Blood Lipid Management on the Clinical Prognosis of Symptomatic Intracranial Atherosclerotic Stenosis（sICASBLM）
Source: ClinicalTrials.gov · Last updated 15 Apr 2026
Brief summary (registry, in English)
sICASBLM is a prospective controlled trial, to asses the impact of improving blood lipid management on clinical outcome of moderate to severe symptomatic intracranial atherosclerotic stenosis patients (LDL-C\>1.8mmol/L) without endovascular therapy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 180 (estimated)
- First submitted
- 23 May 2022
- Start date
- 23 May 2022
- Primary completion date
- 1 May 2026
- Lead sponsor
- Nanjing First Hospital, Nanjing Medical University
- Diseases
- Stroke
- NCT number
- NCT05397405
What you commit to
- Study type: Interventional
- Planned participants: 180
- From 23 May 2022 to the primary completion date, 1 May 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Stenosis caused by vasculitis, arterial dissection and moyamoya disease
- Patients with active bleeding or obvious bleeding tendency
- Severe heart, lung, renal insufficiency, malignant tumor or other malignant diseases, and death is highly likely within 7 days; pregnancy or women who are lactating
- Uncontrolled severe diabetes and hypertension
- Other conditions inappropriate for inclusion judged by investigators
Other
- Contraindications to statins
- There are contraindications to MRI examination or cannot accept MRI examination
Who the study is looking for
- Age ≥18 years
- Symptomatic intracranial atherosclerotic stenosis of moderate to severe, did not receive intravenous thrombolysis, thrombectomy, stent implantation and other intravascular treatment
- low density lipoprotein cholesterol \> 70mg/dl (1.8mmol/L)
- Receive 3T magnetic resonance angiography or multi-mode MR (high resolution is required), angiography can be included, and images for analysis can be obtained.
- Lipid-lowering indications of statins
- Signed an approved informed consents
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanjing First Hospital Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
| Nanjing First Hospital, Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.