NCT05398250Enrolling by invitation
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Source: ClinicalTrials.gov · Last updated 10 Feb 2026
Brief summary (registry, in English)
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability of two suicide prevention strategies tailored for autistic individuals: the Safety Planning Intervention tailored for Autistic individuals (SPI-A) and SPI-A plus structured follow-up contacts (SPI-A+).
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 1665 (estimated)
- First submitted
- 25 May 2022
- Start date
- 23 Aug 2022
- Primary completion date
- Nov 2027
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Autism
- NCT number
- NCT05398250
What you commit to
- Study type: Interventional
- Planned participants: 1665
- From 23 Aug 2022 to the primary completion date, Nov 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- A.3 - Active PRO Arm:
- (B) Clinician Participants
- (C) Health System Leader Participants
Who the study is looking for
- 12-24 years old
- Scheduled for a clinical visit with a consented clinician Exclusion criteria: None
- A.2 - Enhanced EHR-Only Arm:
- Meets inclusion criteria for the Basic EHR-Only arm
- Receives one of the interventions being studied (SPI-A or SPI-A+) as part of routine clinical care
- Meets inclusion criteria for the Enhanced EHR-Only arm
- Referred to the study team by a consented clinician
- Able and willing to provide informed consent (age 18+) or assent and parental/guardian consent (age \< 18)
- Able to speak English (and, if applicable, at least one guardian also able to speak English)
- Employment as a provider serving autistic patients at one of the study sites
- Employment in a role that involves suicide risk intervention with youth patients at a participating clinic
- Able to read and speak English
- Able and willing to provide informed consent
- Health system or clinic leader at one of the study sites
- Employed in a role that provides administrative oversight to clinicians conducting safety plans with patients
- Able to read and speak English
- Able and willing to provide informed consent
Criteria the registry did not label
- (A) Patient Participants
- Please note that that eligibility criteria differ for each distinct patient subgroup as defined below.
- A.1 - Basic EHR-Only Arm
Age in the registry: 12 years to 99 years · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kennedy Krieger Institute Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| University of North Carolina at Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Nationwide Children's Hospital Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Children's Hospital of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Seattle Children's Hospital Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.