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NCT05399368TerminatedPhase 2

An Efficacy and Safety Study of RPT193 in Adults With Atopic Dermatitis

A Phase 2 Study to Evaluate the Efficacy and Safety of RPT193 as Monotherapy in Adults With Moderate-to-Severe Atopic Dermatitis

Source: ClinicalTrials.gov · Last updated 23 Mar 2026

Reason given: Study on clinical hold by FDA

Brief summary (registry, in English)

Phase 2 study of RPT193 in adults with atopic dermatitis

Status (registry)
Terminated
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
229 (actual)
First submitted
26 May 2022
Start date
7 Jun 2022
Primary completion date
24 May 2024
Lead sponsor
RAPT Therapeutics, Inc., a member of the GSK plc group of companies
NCT number
NCT05399368

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Major surgery within 8 weeks of screening
  • Immunodeficiency and/or receipt of immunosuppressive drugs within 4 weeks of baseline
  • Use of systemic Janus kinase (JAK) inhibitor within 8 weeks of baseline
  • Received live or live-attenuated vaccine within 4 weeks of baseline
  • Prior receipt of RPT193

Other illness

  • Uncontrolled diabetes
  • Stage III or IV cardiac failure
  • Severe renal condition

Other

  • Uncontrolled moderate-to-severe asthma

Who the study is looking for

  • Clinically confirmed diagnosis of active atopic dermatitis (AD), according to the revised Hanifin and Rajka criteria
  • 12-month history of AD and had no significant flares in AD for at least 4 weeks before screening
  • inadequate response to a ≥1 month treatment with topical medications
  • Atopic dermatitis covering ≥10% of the body surface area
  • EASI score ≥16
  • Validated Investigator Global Assessment (VIGA) ≥3
  • Use of emollient(s) at least 2x daily for 1 week prior to baseline
  • Negative coronavirus disease (COVID)-19 results at screening

Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (59)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
SimcoDerm Medical and Surgical Dermatology CenterBarrieCanadaUnknown status
Leader ResearchHamiltonCanadaUnknown status
Red Maple Trials Inc.OttawaCanadaUnknown status
Fivenson DermatologyAnn ArborUnited StatesUnknown status
Arlington Research Center, inc.ArlingtonUnited StatesUnknown status
DermResearchAustinUnited StatesUnknown status
DelRicht ResearchBaton RougeUnited StatesUnknown status
Cahaba Dermatology and Skin Health CenterBirminghamUnited StatesUnknown status
Optima Research BoardmanBoardmanUnited StatesUnknown status
MetroBoston Clinical PartnersBrightonUnited StatesUnknown status
Schweiger Dermatology Group, PC Research DivisionColumbiaUnited StatesUnknown status
Florida Academic Centers Research and Education, LLCCoral GablesUnited StatesUnknown status
Driven Research LLCCoral GablesUnited StatesUnknown status
Studies in Dermatology, LLCCypressUnited StatesUnknown status
Dermatology Treatment and Research CenterDallasUnited StatesUnknown status
University Dermatology and Vein ClinicDarienUnited StatesUnknown status
Palm Beach Dermatology GroupDelray BeachUnited StatesUnknown status
California Dermatology & Clinical Research InstituteEncinitasUnited StatesUnknown status
First OC DermatologyFountain ValleyUnited StatesUnknown status
Clinical Trial NetworkHoustonUnited StatesUnknown status
Dawes Fretzin Clinical Research Group, LLCIndianapolisUnited StatesUnknown status
Indiana Clinical and Translational Sciences Institute (CTSI) Clinical Research CenterIndianapolisUnited StatesUnknown status
Forest Hills Dermatology GroupKew GardensUnited StatesUnknown status
Dermatology Research AssociatesLos AngelesUnited StatesUnknown status
Wallace Medical GroupLos AngelesUnited StatesUnknown status
Grimes CenterLos AngelesUnited StatesUnknown status
Skin Sciences, PLLCLouisvilleUnited StatesUnknown status
Skin Care Physicians of GeorgiaMaconUnited StatesUnknown status
Gsi Clinical ResearchMargateUnited StatesUnknown status
Marietta Dermatology Clinical Research, Inc.MariettaUnited StatesUnknown status
Apex Clinical Research CenterMayfield HeightsUnited StatesUnknown status
Markowitz Medical, PLLCNew YorkUnited StatesUnknown status
Juva Skin & Laser CenterNew YorkUnited StatesUnknown status
Ichan School of Medicine at Mount SinaiNew YorkUnited StatesUnknown status
Velocity Clinical ResearchNorth HollywoodUnited StatesUnknown status
Arkansas Research Trials, LLCNorth Little RockUnited StatesUnknown status
Advanced Dermatology of the MidlandsOmahaUnited StatesUnknown status
Skin Specialists PC (Schlessinger MD)OmahaUnited StatesUnknown status
The Indiana Clinical Trials Center, PCPlainfieldUnited StatesUnknown status
Beacon Clinical Research, LLCQuincyUnited StatesUnknown status
Health ConceptsRapid CityUnited StatesUnknown status
West End Dermatology AssociatesRichmondUnited StatesUnknown status
Integrative Skin Science and ResearchSacramentoUnited StatesUnknown status
Medisearch Clinical TrialsSaint JosephUnited StatesUnknown status
St Joseph Dermatology and Vein ClinicSaint JosephUnited StatesUnknown status
Progressive Clinical ResearchSan AntonioUnited StatesUnknown status
Clinical Science InstituteSanta MonicaUnited StatesUnknown status
Georgia Skin & Cancer ClinicSavannahUnited StatesUnknown status
Perseverance Research CenterScottsdaleUnited StatesUnknown status
Jordan Valley Dermatology CenterSouth JordanUnited StatesUnknown status
Premier Clinical ResearchSpokaneUnited StatesUnknown status
Acclaim DermatologySugar LandUnited StatesUnknown status
Complete DermatologySugar LandUnited StatesUnknown status
LENUS Research & Medical Group, LLCSweetwaterUnited StatesUnknown status
ForCare Clinical ResearchTampaUnited StatesUnknown status
Clinical Trials Research InstituteThousand OaksUnited StatesUnknown status
Schweiger Dermatology GroupVeronaUnited StatesUnknown status
Grekin Skin InstituteWarrenUnited StatesUnknown status
Foxhall Research CenterWashington D.C.United StatesUnknown status

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This page is information, not medical advice. Discuss any trial with your doctor.