NCT05404750Active, not recruiting
Harm Reduction in HIV Primary Care for PLWH Who Use Drugs
Impact of Harm Reduction Care in HIV Clinical Settings on Stigma and Health Outcomes
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
People living with HIV (PLWH) who use drugs experience significant health disparities including lower rates of retention in HIV care and higher rates of unsuppressed viral load, resulting in secondary infections and increased mortality. The proposed study will used mixed methods to explore (a) the relationship between healthcare providers' attitudes towards working with PLWH who use drugs and providers' acceptance and practice of structural and relational harm reduction; (b) the degree to which relational harm reduction moderates the effect of intersectional stigma experienced in healthcare settings on patients' perceptions of their relationship with providers; (c) the degree to which structural HR moderates the relationship between the patient-provider relationship and clinical outcomes, and (d) whether patient-perceived HR approaches to care are directly associated with HIV clinical outcomes. The study will also use these findings to inform the development and pre-testing of an intervention to operationalize harm reduction in HIV clinical settings, using stakeholder-engaged and human-centered design approaches, presenting a novel path to reducing HIV health inequities for PLWH who use drugs.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 641 (actual)
- First submitted
- 19 May 2022
- Start date
- 20 Apr 2022
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- University of Pittsburgh
- Diseases
- HIV
- NCT number
- NCT05404750
What you commit to
- Study type: Observational
- Participants enrolled: 641
- From 20 Apr 2022 to the primary completion date, 30 Jun 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
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Who the study is looking for
- Providers' Inclusion Criteria
- Working at one of our 3 study sites (UPMC HIV/AIDS Program, Positive Health Clinic, or 1917 Clinic) or one of their partner sites offering substance use treatment (Internal Medicine Recovery Engagement Program, Center for Inclusion Health, or UAB's Outpatient-Based Opioid Treatment Clinic) for at least one year
- Providing service or care to PLWH or people who use drugs at high risk for HIV acquisition
- Working in one of the following positions: front desk/patient engagement, social worker, nurse, medical assistant, advanced practice provider, or physician
- Able to verbally consent, read, and speak English
- Patient Inclusion Criteria
- Living with HIV
- Age 18 or older
- Able to verbally consent, read, and speak English
- Receiving HIV medical care from one of the study sites for at least one year
- Lifetime or recent use (past 3 months) of illicit substances (excluding marijuana) or prescription drugs for non-medical reasons in accordance with the NIDA-Modified ASSIST 2.0.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| University of Pittsburgh Medical Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Allegheny Health Network Research Institute Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.