NCT05408559WithdrawnPhase 1/2
Prevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ES
Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement Sulforaphane
Source: ClinicalTrials.gov · Last updated 29 Jun 2026
Reason given: Had issue enrolling subjects.
Brief summary (registry, in English)
Our local IRB approved clinical studies seeking proof of principle for the hypothesis that SFN can be safely administered to humans at doses sufficient to protect age-associated cardiac dysfunctions. Beneficial effects of SFN-therapy will be assessed by Pre- and post-intervention echocardiography, and exercise endurance at 0 and 24 weeks. Peripheral blood cells from treated and control subjects will be compared for mitochondrial respiratory function, oxidative damage, pro-inflammatory cytokines, and expression of antioxidant \& anti-electrophile genes.
- Status (registry)
- Withdrawn
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 17 Mar 2022
- Start date
- 1 Jul 2022
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- Texas Tech University Health Sciences Center
- Diseases
- Heart failure
- NCT number
- NCT05408559
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- On oxygen therapy
Other illness
- Diagnosis of active cancer
Other
- Inability to provide informed consent
- Inability to read and understand the SF-36 in English
- Participants using over the counter antioxidant supplements
- Participants with pulmonary or other issues which restrict walking capacity
Who the study is looking for
- Age > 60 years
- Diagnosis of HFpEF (HF symptoms with a normal EF (>/=50 %)
- Ability to walk more than 500 feet (by self-report)
- Willing to avoid taking all over the counter antioxidant phytochemical supplements (vegetable or fruit-containing supplement pills) during the study
Age in the registry: 60 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Texas Tech University Health Sciences Center (TTUHSC) | Lubbock | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.