NCT05408637CompletedPhase 2
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder
Transcranial Photobiomodulation for Executive Function in Bipolar Disorder (TPEB)
Source: ClinicalTrials.gov · Last updated 28 Aug 2025
Brief summary (registry, in English)
Transcranial light therapy, or transcranial photobiomodulation (tPBM), is a treatment that stimulates the brain by applying near-infrared light to the forehead. Transcranial light therapy has been found to promote brain metabolism, which may help improve executive function in people with bipolar disorder. The research team proposes a novel approach to treating bipolar disorder by using transcranial light therapy.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 13 (actual)
- First submitted
- 17 May 2022
- Start date
- 9 Aug 2022
- Primary completion date
- 14 May 2024
- Lead sponsor
- Paolo Cassano
- Diseases
- Bipolar disorder
- NCT number
- NCT05408637
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 13
- From 9 Aug 2022 to the primary completion date, 14 May 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Changes in medications or use of augmentative devices and other interventions in the 2 weeks prior to the study
Other illness
- Currently in alcohol or substance use disorder (meeting criteria in the past 3 months)
- Unstable medical conditions
- Failure to meet standard MRI safety requirements (e.g. claustrophobia, non-removable piercings, implanted medical devices, other non-removable metals)
Other
- Currently in depressive, manic, or mixed episode
- Currently psychotic
- Judged to be at serious and imminent suicidal risk
- Inability to consent or to complete study procedures
- Participation in other clinical research trials that may influence primary outcomes or adherence to the proposed study
- Current pregnancy.
Who the study is looking for
- Adults between the ages of 18 and 65
- Diagnosis of bipolar disorder
- Currently experiencing symptoms of impulsivity
- Vision normal or corrected to normal with contacts
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mass General Hospital Navy Yard Building 149 Coordinator of this site? Confirm its status | Charlestown | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.