NCT05411081Active, not recruitingPhase 2
Testing Cabozantinib With or Without Atezolizumab in Patients With Advanced Papillary Kidney Cancer, PAPMET2 Trial
A Phase II Randomized Trial of Cabozantinib (NSC #761968) With or Without Atezolizumab (NSC #783608) in Patients With Advanced Papillary Renal Cell Carcinoma (PAPMET2)
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
This phase II trial compares the effect of atezolizumab in combination with usual treatment with cabozantinib to cabozantinib alone in patients with papillary renal cell carcinoma that has spread from where it first started (primary site) to other places in the body (metastatic). Papillary renal cell carcinoma (PRCC) is a type of kidney cancer that forms in the lining of the tiny tubes in the kidney that return filtered substances that the body needs back to the blood and remove extra fluid and waste as urine. Most papillary tumors look like long, thin finger-like growths under a microscope. It is also called papillary kidney cancer or PRCC. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the tumor and may interfere with the ability of tumor cells to grow and spread. Cabozantinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals tumor cells to multiply and may also prevent the growth of new blood vessels that tumors need to grow. By these actions it may help slow or stop the spread of tumor cells. Combination therapy with atezolizumab and cabozantinib may shrink the tumor and allow a longer survival time in patients with metastatic renal cell carcinoma.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 7 Jun 2022
- Start date
- 24 Mar 2023
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Kidney cancer
- NCT number
- NCT05411081
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 200
- From 24 Mar 2023 to the primary completion date, 1 Jul 2027
- 198 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Participants must have a histologically confirmed diagnosis of metastatic papillary renal cell carcinoma (PRCC), either type 1 or type 2. (NOTE: A designation of type 1 or type 2 should be made by the local pathologist if possible but is not required). Mixed histologies which contain type 1 or type 2 along with any other RCC histology/histologies will be allowed provided that they contain a papillary component
- Participants must have measurable disease per RECIST 1.1 criteria. All measurable lesions must be assessed by CT or MRI within 28 days prior to registration. All non-measurable lesions must be assessed by CT or MRI, or nuclear medicine bone scan within 42 days prior to registration. The CT from a combined positron emission tomography (PET)/CT may be used to document only non-measurable disease unless it is of diagnostic quality. If there is clinical suspicion for bone metastases at the time of enrollment (at the discretion of the investigator), bone scan must be performed at baseline (within 42 days prior to registration)
- Participants with new or progressive brain metastases (active brain metastases) must not require immediate central nervous system (CNS) specific treatment at the time of study registration or anticipated during the first cycle of therapy. Patients with leptomeningeal disease are excluded from enrolling
- Participants with measurable disease, per RECIST version (v)1.1, must be present outside the CNS
- Participants must have no history of intracranial hemorrhage or spinal cord hemorrhage
- Participants must not have undergone stereotactic radiotherapy within 7 days prior to initiation of study treatment, whole-brain radiotherapy within 14 days prior to initiation of study treatment, or neurosurgical resection within 28 days prior to initiation of study treatment
- Participants must not have ongoing requirements for corticosteroids as therapy for CNS disease
- Participants, if needed, must receive a stable dose of anti-convulsant therapy
- Participants must not have cavitating pulmonary lesions
- Participants must not have uncontrolled pleural effusions, pericardial effusions, or ascites requiring recurrent drainage procedures (once monthly or more frequently). Participants with indwelling catheters (e.g., PleurX \[registered trademark\]) are allowed
- Participants must not have tumor invading the gastrointestinal (GI) tract or evidence of endotracheal or endobronchial tumor within 28 days prior to registration
- Participants must not have evidence of tumor invading or encasing any major blood vessels
- Participants must not have had major surgery within 28 days prior to registration, and participants must have recovered from any adverse effects of surgery
- Participants must not have had prior treatment with cabozantinib for any reason
- Participants must not have had prior treatment or adjuvant therapy with PD-1/PD-L1 checkpoint inhibitors for any reason within the past 6 months
- Participants must not have received more than one prior systemic therapy for advanced or metastatic renal cell carcinoma with the exception of another VEGF inhibitor Food and Drug Administration (FDA)-approved for advanced RCC (i.e., pazopanib, bevacizumab, sorafenib or axitinib). If a participant develops metastatic disease within six months of discontinuation of adjuvant therapy, this will constitute one prior systemic therapy for advanced or metastatic RCC. If a patient develops metastatic disease and more than six months has elapsed since discontinuation of adjuvant therapy, this will not constitute prior systemic therapy for advanced or metastatic RCC
- Participants must not take within 14 days prior to registration, nor plan to take while on protocol treatment, any strong CYP3A4 inhibitors (e.g. boceprevir, cobicistat, danoprevir, elvitegravir/RIT, fluvoxamine, indinavir, itraconazole, ketoconazole, lopinavir/RIT, nefazodone, nelfinavir, posaconazole, ritonavir, telaprevir, telithromycin, tipranavir/RIT, or voriconazole,); Please refer to https://drug-interactions.medicine.iu.edu/MainTable.aspx for the updated CYP3A4 inhibitors or inducers
- Participants must not take within 14 days prior to registration, nor plan to take while on protocol treatment, any strong CYP3A4 inducers (e.g. avasimibe, phenytoin, rifampin, rifabutin); Please refer to https://drug-interactions.medicine.iu.edu/MainTable.aspx for the updated CYP3A4 inhibitors or inducers
- Participants must complete all prior radiation therapy at least 14 days prior to registration. Participants must have recovered to =\< grade 1 from all associated toxicities at the time of registration unless the toxicity is determined to be not clinically significant by the registering investigator
- Participants must not be receiving or planning to receive any other investigational agents at time of registration
- Participants must not have been diagnosed with a clinically significant autoimmune disease, exceptions such as diabetes, eczema, and vitiligo are allowed. Other non-clinically significant autoimmune diseases are allowed if approved by the registering investigator
- Participants must not be on steroid doses \> 10 mg prednisone equivalent. Replacement steroid doses for adrenal insufficiency will be allowed. Also, short duration steroid therapy to prevent allergic reactions are acceptable (e.g. prior to CT imaging)
- Participants must be \>= 18 years of age
- Participants must have a complete physical examination and medical history within 28 days prior to registration
- Participants must have a Zubrod performance status of 0-2
- White blood count (WBC) \>= 2 x 10\^3/uL (within 28 days prior to registration)
- Absolute neutrophil count (ANC) \>= 1.5 x 10\^3/uL (within 28 days prior to registration)
- Platelet count \>= 100 x 10\^3/uL (within 28 days prior to registration)
- Lymphocyte count \>= 0.5 x 10\^3/uL (within 28 days prior to registration)
- Hemoglobin (\>= 9 g/dL) (within 28 days prior to registration). Participants may be transfused to meet this criterion
- Total serum bilirubin =\< 1.5 x the institutional upper limit of normal (ULN) unless history of Gilbert's disease (within 28 days prior to registration). Participants with history of Gilbert's disease must have total bilirubin =\< 5 x institutional ULN
- Aspartate aminotransferase (AST) must be =\< 3 x the institutional ULN unless the liver is involved with the tumor, in which case serum transaminase (SGOT) must be =\< 5 x the institutional ULN (within 28 days prior to registration)
- Alanine aminotransferase (ALT), must be =\< 3 x the institutional ULN unless the liver is involved with the tumor, in which case serum transaminase (SGPT) must be =\< 5 x the institutional ULN (within 28 days prior to registration)
- Participants must have serum creatinine =\< 2 x the institutional ULN OR creatinine clearance (either measured or calculated) \> 30 mL/min and obtained within 28 days prior to registration
- Participants must not have any clinical evidence of congestive heart failure (CHF) (specifically, New York Heart Association \[NYHA\] class III \[moderate\] or class IV \[severe\]) at the time of registration
- Participants must not have known history of congenital long QT syndrome and must not have experienced unstable angina pectoris, clinically significant cardiac arrhythmias, or stroke (transient ischemic attack \[TIA\] or other ischemic event) within 90 days prior to registration
- Participants must not have experienced myocardial infarction or thromboembolic event requiring anticoagulation within 90 days of registration, unless clinically stable with ongoing medical management
- Participants must have urine protein \< 3+ within 28 days prior to registration. If urine protein is 3+ or greater, then urine protein by 24-hour collection must show less than 3 grams of protein
- Participants must have documented blood pressure of systolic blood pressure (SBP) \< 150 mm Hg or diastolic blood pressure (DBP) \< 100 mm Hg within 14 days prior to registration
- Participants with known human immunodeficiency virus (HIV) must be on effective anti-retroviral therapy at registration and have undetectable viral load within 6 months of registration
- Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load while on suppressive therapy within 6 months prior to registration, if indicated
- Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants currently being treated for HCV infection must have undetectable HCV viral load within 6 months prior to registration
- Participants must be able to take oral medications (i.e., swallow pills whole). Participants must not have gastrointestinal tract disease resulting in an inability to take oral medication or a requirement for IV alimentation, prior surgical procedures that could in the opinion of the treating investigator affect absorption, or active peptic ulcer disease. Participants with intractable nausea or vomiting are not eligible
- Participants must not have had any clinically-significant GI bleeding within 3 months prior to registration and participants must not have a GI disorder which (at the discretion of the investigator) bears a high risk of perforation or fistula (e.g. Crohn's disease)
- Participants must not have had hemoptysis of \>= (2.5 mL) of red blood, and do not demonstrate any other signs indicative of pulmonary hemorrhage within 3 months prior registration
- Participants with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- Participants must not be pregnant or nursing, due to VEGF therapy being toxic to embryogenesis. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen
- Participants must not be on warfarin, at therapeutic doses. Low dose aspirin for cardio-protection (per local applicable guidelines) and low molecular weight heparin (LMWH) are allowed
- Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System
- Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
- NOTE: For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations
- As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (198)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mary Greeley Medical Center Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| McFarland Clinic - Ames Coordinator of this site? Confirm its status | Ames | United States | Unknown status |
| Community Hospital of Anaconda Coordinator of this site? Confirm its status | Anaconda | United States | Unknown status |
| Kaiser Permanente-Anaheim Coordinator of this site? Confirm its status | Anaheim | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Coordinator of this site? Confirm its status | Ankeny | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Unknown status |
| UH Seidman Cancer Center at UH Avon Health Center Coordinator of this site? Confirm its status | Avon | United States | Unknown status |
| Kaiser Permanente-Baldwin Park Coordinator of this site? Confirm its status | Baldwin Park | United States | Unknown status |
| Johns Hopkins University/Sidney Kimmel Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Bronson Battle Creek Coordinator of this site? Confirm its status | Battle Creek | United States | Unknown status |
| UHHS-Chagrin Highlands Medical Center Coordinator of this site? Confirm its status | Beachwood | United States | Unknown status |
| Kaiser Permanente-Bellflower Coordinator of this site? Confirm its status | Bellflower | United States | Unknown status |
| Saint Vincent Frontier Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Billings Clinic Cancer Center Coordinator of this site? Confirm its status | Billings | United States | Unknown status |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| Saint Luke's Cancer Institute - Boise Coordinator of this site? Confirm its status | Boise | United States | Unknown status |
| McFarland Clinic - Boone Coordinator of this site? Confirm its status | Boone | United States | Unknown status |
| Bozeman Health Deaconess Hospital Coordinator of this site? Confirm its status | Bozeman | United States | Unknown status |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Caldwell Coordinator of this site? Confirm its status | Caldwell | United States | Unknown status |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Unknown status |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Unknown status |
| Caro Cancer Center Coordinator of this site? Confirm its status | Caro | United States | Unknown status |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Unknown status |
| Duke Cancer Center Cary Coordinator of this site? Confirm its status | Cary | United States | Unknown status |
| Miami Valley Hospital South Coordinator of this site? Confirm its status | Centerville | United States | Unknown status |
| Vandalia Health/CAMC Institute for Academic Medicine Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Unknown status |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Siteman Cancer Center at Saint Peters Hospital Coordinator of this site? Confirm its status | City of Saint Peters | United States | Unknown status |
| Case Western Reserve University Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Southeastern Medical Oncology Center-Clinton Coordinator of this site? Confirm its status | Clinton | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Unknown status |
| Kootenai Health - Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Unknown status |
| Mercy Hospital Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| Siteman Cancer Center at West County Hospital Coordinator of this site? Confirm its status | Creve Coeur | United States | Unknown status |
| UT Southwestern/Simmons Cancer Center-Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| UT Southwestern Simmons Cancer Center - RedBird Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Carle at The Riverfront Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Premier Blood and Cancer Center Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Miami Valley Hospital North Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Dayton Physician LLC - Englewood Coordinator of this site? Confirm its status | Dayton | United States | Unknown status |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Northwestern Medicine Cancer Center Kishwaukee Coordinator of this site? Confirm its status | DeKalb | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Mercy Medical Center - Des Moines Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Wayne State University/Karmanos Cancer Institute Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Illinois CancerCare-Dixon Coordinator of this site? Confirm its status | Dixon | United States | Unknown status |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Unknown status |
| Epic Care-Dublin Coordinator of this site? Confirm its status | Dublin | United States | Unknown status |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Unknown status |
| Fairview Southdale Hospital Coordinator of this site? Confirm its status | Edina | United States | Unknown status |
| Carle Physician Group-Effingham Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Unknown status |
| Epic Care Partners in Cancer Care Coordinator of this site? Confirm its status | Emeryville | United States | Unknown status |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Unknown status |
| Farmington Health Center Coordinator of this site? Confirm its status | Farmington | United States | Unknown status |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Unknown status |
| Weisberg Cancer Treatment Center Coordinator of this site? Confirm its status | Farmington Hills | United States | Unknown status |
| Cancer Hematology Centers - Flint Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Genesee Hematology Oncology PC Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Kaiser Permanente-Fontana Coordinator of this site? Confirm its status | Fontana | United States | Unknown status |
| McFarland Clinic - Trinity Cancer Center Coordinator of this site? Confirm its status | Fort Dodge | United States | Unknown status |
| UT Southwestern/Simmons Cancer Center-Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Unknown status |
| Atrium Medical Center-Middletown Regional Hospital Coordinator of this site? Confirm its status | Franklin | United States | Unknown status |
| Saint Luke's Cancer Institute - Fruitland Coordinator of this site? Confirm its status | Fruitland | United States | Unknown status |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Unknown status |
| Northwestern Medicine Cancer Center Delnor Coordinator of this site? Confirm its status | Geneva | United States | Unknown status |
| Banner MD Anderson Cancer Center Coordinator of this site? Confirm its status | Gilbert | United States | Unknown status |
| Northwestern Medicine Glenview Outpatient Center Coordinator of this site? Confirm its status | Glenview | United States | Unknown status |
| Southeastern Medical Oncology Center-Goldsboro Coordinator of this site? Confirm its status | Goldsboro | United States | Unknown status |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Northwestern Medicine Grayslake Outpatient Center Coordinator of this site? Confirm its status | Grayslake | United States | Unknown status |
| Benefis Sletten Cancer Institute Coordinator of this site? Confirm its status | Great Falls | United States | Unknown status |
| Miami Valley Cancer Care and Infusion Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Hackensack University Medical Center Coordinator of this site? Confirm its status | Hackensack | United States | Unknown status |
| Kaiser Permanente South Bay Coordinator of this site? Confirm its status | Harbor City | United States | Unknown status |
| Kaiser Permanente-Irvine Coordinator of this site? Confirm its status | Irvine | United States | Unknown status |
| University of Mississippi Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Southeastern Medical Oncology Center-Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| McFarland Clinic - Jefferson Coordinator of this site? Confirm its status | Jefferson | United States | Unknown status |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Beacon Kalamazoo Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| West Michigan Cancer Center Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Logan Health Medical Center Coordinator of this site? Confirm its status | Kalispell | United States | Unknown status |
| Kettering Medical Center Coordinator of this site? Confirm its status | Kettering | United States | Unknown status |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Unknown status |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Unknown status |
| University of Michigan Health - Sparrow Lansing Coordinator of this site? Confirm its status | Lansing | United States | Unknown status |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| University of Arkansas for Medical Sciences Coordinator of this site? Confirm its status | Little Rock | United States | Unknown status |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Unknown status |
| Kaiser Permanente West Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Kaiser Permanente Los Angeles Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Unknown status |
| Saint John's Hospital - Healtheast Coordinator of this site? Confirm its status | Maplewood | United States | Unknown status |
| Saint Mary's Oncology/Hematology Associates of Marlette Coordinator of this site? Confirm its status | Marlette | United States | Unknown status |
| McFarland Clinic - Marshalltown Coordinator of this site? Confirm its status | Marshalltown | United States | Unknown status |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Unknown status |
| Contra Costa Regional Medical Center Coordinator of this site? Confirm its status | Martinez | United States | Unknown status |
| Carle Physician Group-Mattoon/Charleston Coordinator of this site? Confirm its status | Mattoon | United States | Unknown status |
| Loyola University Medical Center Coordinator of this site? Confirm its status | Maywood | United States | Unknown status |
| Saint Luke's Cancer Institute - Meridian Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| East Jefferson General Hospital Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Mary Bird Perkins Cancer Center - Metairie Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| LSU Healthcare Network / Metairie Multi-Specialty Clinic Coordinator of this site? Confirm its status | Metairie | United States | Unknown status |
| Abbott-Northwestern Hospital Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Marshfield Medical Center - Minocqua Coordinator of this site? Confirm its status | Minocqua | United States | Unknown status |
| Community Medical Center Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| Trinity Health Muskegon Hospital Coordinator of this site? Confirm its status | Muskegon | United States | Unknown status |
| Saint Luke's Cancer Institute - Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Unknown status |
| Providence Newberg Medical Center Coordinator of this site? Confirm its status | Newberg | United States | Unknown status |
| Touro Infirmary Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| University Medical Center New Orleans Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Niles Hospital Coordinator of this site? Confirm its status | Niles | United States | Unknown status |
| Cancer and Hematology Centers of Western Michigan - Norton Shores Coordinator of this site? Confirm its status | Norton Shores | United States | Unknown status |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Unknown status |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| Saint Alphonsus Cancer Care Center-Ontario Coordinator of this site? Confirm its status | Ontario | United States | Unknown status |
| Kaiser Permanente-Ontario Coordinator of this site? Confirm its status | Ontario | United States | Unknown status |
| Providence Willamette Falls Medical Center Coordinator of this site? Confirm its status | Oregon City | United States | Unknown status |
| Northwestern Medicine Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Unknown status |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Unknown status |
| Kaiser Permanente - Panorama City Coordinator of this site? Confirm its status | Panorama City | United States | Unknown status |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Unknown status |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Unknown status |
| Cancer Center at Saint Joseph's Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| FirstHealth of the Carolinas-Moore Regional Hospital Coordinator of this site? Confirm its status | Pinehurst | United States | Unknown status |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Unknown status |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Kootenai Clinic Cancer Services - Post Falls Coordinator of this site? Confirm its status | Post Falls | United States | Unknown status |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Unknown status |
| Duke Cancer Center Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Unknown status |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Unknown status |
| UT Southwestern Clinical Center at Richardson/Plano Coordinator of this site? Confirm its status | Richardson | United States | Unknown status |
| VCU Massey Cancer Center at Stony Point Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| VCU Massey Comprehensive Cancer Center Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Kaiser Permanente-Riverside Coordinator of this site? Confirm its status | Riverside | United States | Unknown status |
| UW Health Carbone Cancer Center Rockford Coordinator of this site? Confirm its status | Rockford | United States | Unknown status |
| University of California Davis Comprehensive Cancer Center Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| MyMichigan Medical Center Saginaw Coordinator of this site? Confirm its status | Saginaw | United States | Unknown status |
| Oncology Hematology Associates of Saginaw Valley PC Coordinator of this site? Confirm its status | Saginaw | United States | Unknown status |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Unknown status |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Unknown status |
| Park Nicollet Clinic - Saint Louis Park Coordinator of this site? Confirm its status | Saint Louis Park | United States | Unknown status |
| Regions Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| United Hospital Coordinator of this site? Confirm its status | Saint Paul | United States | Unknown status |
| Huntsman Cancer Institute/University of Utah Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| University of Texas Health Science Center at San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Kaiser Permanente-San Diego Zion Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Kootenai Clinic Cancer Services - Sandpoint Coordinator of this site? Confirm its status | Sandpoint | United States | Unknown status |
| Kaiser Permanente-San Marcos Coordinator of this site? Confirm its status | San Marcos | United States | Unknown status |
| Memorial Hospital East Coordinator of this site? Confirm its status | Shiloh | United States | Unknown status |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Unknown status |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Siteman Cancer Center at Christian Hospital Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Siteman Cancer Center-South County Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Unknown status |
| MyMichigan Medical Center Tawas Coordinator of this site? Confirm its status | Tawas City | United States | Unknown status |
| Cotton O'Neil Cancer Center / Stormont Vail Health Coordinator of this site? Confirm its status | Topeka | United States | Unknown status |
| Munson Medical Center Coordinator of this site? Confirm its status | Traverse City | United States | Unknown status |
| Upper Valley Medical Center Coordinator of this site? Confirm its status | Troy | United States | Unknown status |
| Oklahoma Cancer Specialists and Research Institute-Tulsa Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| Saint Luke's Cancer Institute - Twin Falls Coordinator of this site? Confirm its status | Twin Falls | United States | Unknown status |
| Carle Cancer Center Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Epic Care Cyberknife Center Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| Northwestern Medicine Cancer Center Warrenville Coordinator of this site? Confirm its status | Warrenville | United States | Unknown status |
| Illinois CancerCare - Washington Coordinator of this site? Confirm its status | Washington | United States | Unknown status |
| MedStar Georgetown University Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Coordinator of this site? Confirm its status | Waukee | United States | Unknown status |
| Saint Mary's Oncology/Hematology Associates of West Branch Coordinator of this site? Confirm its status | West Branch | United States | Unknown status |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Unknown status |
| Kaiser Permanente-Woodland Hills Coordinator of this site? Confirm its status | Woodland Hills | United States | Unknown status |
| University of Michigan Health - West Coordinator of this site? Confirm its status | Wyoming | United States | Unknown status |
| Huron Gastroenterology PC Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.