NCT05411614Recruiting
Hybrid Ablation of Atrial Fibrillation in Heart Failure
A Randomised Controlled Trial Comparing Convergent Hybrid Ablation to Catheter Ablation in Patients With Persistent Atrial Fibrillation and Heart Failure
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 20 May 2022
- Start date
- 25 Jun 2022
- Primary completion date
- May 2026
- Lead sponsor
- St. George's Hospital, London
- Diseases
- Heart failure, Atrial fibrillation
- NCT number
- NCT05411614
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 25 Jun 2022 to the primary completion date, May 2026
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous open-heart surgery
- Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable)
- Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures
Other illness
- Not yet optimised from a medical or lifestyle perspective for AF or heart failure
- Active infection, oesophageal ulcer stricture or oesophageal varices
- Severe valvular heart disease
- Unstable coronary artery disease
- Uncontrolled ventricular arrhythmia
- Heart attack or stroke within the last 90 days
Age
- Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months
Other
- Unable to provide written consent
- Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation
Who the study is looking for
- Age ≥ 18 years
- Persistent or Long-standing Persistent AF
- Dilated left atrium (at least moderately dilated)
- Suitable for either procedure
- LVEF \< 50%
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ashford & St Peters Hospital NHS Trust Coordinator of this site? Confirm its status | Chertsey | United Kingdom | Recruiting |
| Epsom General Hospital Coordinator of this site? Confirm its status | Epsom | United Kingdom | Recruiting |
| St Anthonys Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Active, not recruiting |
| Cromwell Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Active, not recruiting |
| St Georges University of London Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Royal Surrey County Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| St Georges at Kingston Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.