NCT05411822Completed
Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment
Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment and Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 24 Jun 2025
Brief summary (registry, in English)
The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 36 (actual)
- First submitted
- 2 Jun 2022
- Start date
- 14 Jun 2021
- Primary completion date
- 31 May 2024
- Lead sponsor
- Icahn School of Medicine at Mount Sinai
- Diseases
- Alzheimer disease
- NCT number
- NCT05411822
What you commit to
- Study type: Interventional
- Participants enrolled: 36
- From 14 Jun 2021 to the primary completion date, 31 May 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- use of sleep medications
- use of antidepressant medication
Other illness
- extensive brain vascular disease
- Parkinson's disease
- bipolar disorder
- diabetes
Other
- seasonal depression
- high blood pressure
- obstructing cataracts
- macular degeneration
- diabetic retinopathy
- use of melatonin supplements
- use of beta blockers
Who the study is looking for
- mild cognitive impairment
- age matched healthy control
- macular pigment density either \< 0.3 or \> 0.5
Age in the registry: 55 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Light and Health Research Center at Mount Sinai Coordinator of this site? Confirm its status | Menands | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.