Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer

Prior treatment

• Patients in whom an optimal or complete cytoreduction cannot be performed will be excluded at the time of surgery and be replaced

Other illness

• History of breast cancer or previous malignancy within 5 years prior to inclusion, with the exception of radically excised basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• History or current diagnosis of inflammatory bowel disease
• History of allergic reactions to compounds of similar chemical or biologic composition to cisplatin, carboplatin, and paclitaxel
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia

Other

• Low grade serious carcinoma of the ovary or borderline ovarian tumors

• Ability to understand (English-speaking), and willingness to sign a written, informed consent
• Age \> 18 years old
• Newly diagnosed stage III or IV epithelial (serous, mucinous, or endometrioid) ovarian, fallopian tube or peritoneal cancer diagnosed by:
  • Biopsy/histology (either by interventional radiology or laparoscopy) OR
  • Cytology; If diagnosis is based on cytology the following criteria must be met:
  • Immunohistochemistry on the block from cytology to demonstrate Mullerian origin
  • Presence of pelvic mass AND CA 125 \> 200kU/I AND CA125/CEA ratio \> 25 at initial diagnosis
  • Omental cake or other metastases larger than 2 cm in the upper abdomen and/or regional lymph node metastasis irrespective of size (diagnosed by computed tomography \[CT\]/magnetic resonance imaging \[MRI\], ultrasound, or laparoscopy)
• Patient planned for or currently receiving neoadjuvant chemotherapy due to the fact that optimal primary CRS was determined not to be feasible by the primary surgeon
• Patient must be planned or scheduled to undergo interval cytoreductive surgery after cycle 3-4 of neoadjuvant surgery
• Completion of three cycles of neoadjuvant chemotherapy (NACT) with standard therapy (carboplatin \[area under the curve (AUC) 5-6\] day \[D\]1 + paclitaxel \[175 mg/m\^2\] D1 every 3 weeks)
  • Following 3-4 cycles of NACT partial or complete response
  • Following 3-4 cycles of NACT at least 50% decrease in CA-125 level between pre-cycle 1 and post-cycle 3/prior to surgery
• Fit for major surgery, American Society of Anesthesiologists (ASA )1 or ASA 2
• Eastern Cooperative Oncology Group (ECOG) performance-status score of 0-2
• Serum creatinine \< 1.4 mg/dL
• Creatinine clearance \> 60 ml/min (Cockcroft-Gault formula)
• White blood cell count \> 3.5 x 10\^9 cells/L
• Absolute neutrophil count \> 1.5 kg/ul
• Platelets \> 100,000/ul
• Total bilirubin within 1.5 x normal institutional limits
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x institutional upper limit of normal
• For quality of life assessment, baseline questionnaires should be filled in before randomization