NCT05421208Active, not recruiting
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
Source: ClinicalTrials.gov · Last updated 15 Jul 2026
Brief summary (registry, in English)
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections. This syndrome affects mostly women (\~80%), present with chronic tachycardia and Orthostatic intolerance symptoms without any identifiable cause. In addition, non-specific symptoms such as fatigue, headache, and "brain fog", commonly described in POTS patients are also present in this novel condition, recently named post-COVID-19 tachycardia syndrome, POTS variant. Reduced Vagal activity and unresolved inflammation is post-COVID-19 POTS is hypothesized as the cause of Long COVID
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 14 Jun 2022
- Start date
- 1 Jun 2022
- Primary completion date
- 13 Jul 2026
- Lead sponsor
- Vanderbilt University Medical Center
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT05421208
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 1 Jun 2022 to the primary completion date, 13 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic use of steroids, NSAIDs.
- On biologics such as anti-IL6 (omalizumab) and anti-TNF-alpha drugs
Other illness
- Heart Disease: Myocardial Infarction, angina, heart failure
- History of stroke, or transient ischemic attack
- Uncontrolled hypertension defined as persistent blood pressure \>140/90.
- Diabetes Mellitus Type 1 or Type 2. ,
- Mental conditions rendering a subject unable to understand the nature, scope and possible consequences of the study.
- History of seizures.
Lab values
- Impaired renal function test (eGFR\<60 mL/min/1.73m2).
Other
- Undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty, valve replacement, pacemaker placement or other vascular surgeries)
- Post-menopausal women.
- Impaired Hepatic function
- Ongoing substance abuse.
- Pregnancy or breastfeeding
Who the study is looking for
- Prior RT-PCR-confirmed COVID-19 infection.
- Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (\>30 bpm) and chronic (\>3 months) pre-syncopal symptoms.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.