NCT05424562Terminated
A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada
Capturing Canadian Real-World Data for AML Chemotherapy Ineligible Patients on Venetoclax (LIVEN)
Source: ClinicalTrials.gov · Last updated 29 Sept 2026
Reason given: Strategic Considerations
Brief summary (registry, in English)
Acute Myeloid Leukemia (AML) is a cancer of the blood and bone marrow and is the most common acute leukemia in adults. This study will evaluate how well venetoclax works to treat AML in adult participants who are ineligible for intensive induction chemotherapy in Canada. Venetoclax is a drug approved to treat Acute Myeloid Leukemia (AML). All study participants will receive Venetoclax as prescribed by their study doctor in accordance with approved local label. Adult participants with a new diagnosis of AML who are ineligible for intensive induction chemotherapy will be enrolled. Around 200 participants will be enrolled in the study in approximately 15-20 sites in Canada. Participants will receive venetoclax tablets to be taken by mouth daily according to the approved local label. The duration of the study is approximately 36 months. There is expected to be no additional burden for participants in this trial. All study visits will occur during routine clinical practice and participants will be followed for 36 months.
- Status (registry)
- Terminated
- Study type
- Observational
- Enrollment
- 210 (actual)
- First submitted
- 15 Jun 2022
- Start date
- 7 Sept 2022
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- AbbVie
- Diseases
- Acute myeloid leukemia
- NCT number
- NCT05424562
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in an interventional clinical trial within 30 days prior to venetoclax treatment initiation.
Who the study is looking for
- Diagnosis of Acute Myeloid Leukemia (AML).
- Ineligible for intensive chemotherapy, determined by the physician's assessment of age, Eastern Cooperative Oncology Group Performance Status (ECOG-PS), comorbidities, regional guidelines, and institutional practice.
- Participant for whom the physician has decided to initiate venetoclax treatment in accordance with the local label. The decision to treat with venetoclax is made by the physician prior to any decision to approach the participant to participate in this study.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Tom Baker Cancer Centre /ID# 248113 | Calgary | Canada | Unknown status |
| University of Alberta Hospital /ID# 251531 | Edmonton | Canada | Unknown status |
| Queen Elizabeth II Health Sciences Centre - Victoria General /ID# 246514 | Halifax | Canada | Unknown status |
| Juravinski Cancer Centre /ID# 247183 | Hamilton | Canada | Unknown status |
| Kingston Health Sciences Centre /ID# 253439 | Kingston | Canada | Unknown status |
| London Health Sciences Center- University Hospital /ID# 248027 | London | Canada | Unknown status |
| The Moncton Hospital /ID# 247277 | Moncton | Canada | Unknown status |
| Disc_Royal Victoria Hospital / McGill University Health Centre /ID# 249704 | Montreal | Canada | Unknown status |
| Lakeridge Health - Oshawa /ID# 246412 | Oshawa | Canada | Unknown status |
| Allan Blair Cancer Centre /ID# 247663 | Regina | Canada | Unknown status |
| Saskatoon Cancer Centre /ID# 247181 | Saskatoon | Canada | Unknown status |
| CIUSSS de l'Estrie - CHUS /ID# 248915 | Sherbrooke | Canada | Unknown status |
| Eastern Regional Health Authority /ID# 250241 | St. John's | Canada | Unknown status |
| BC Cancer - Surrey /ID# 257515 | Surrey | Canada | Unknown status |
| Thunder Bay Regional Research Institute /ID# 249163 | Thunder Bay | Canada | Unknown status |
| Sunnybrook Health Sciences Centre /ID# 251966 | Toronto | Canada | Unknown status |
| University Health Network_Princess Margaret Cancer Centre /ID# 249607 | Toronto | Canada | Unknown status |
| Vancouver General Hospital /ID# 245438 | Vancouver | Canada | Unknown status |
| BC Cancer - Victoria /ID# 257339 | Victoria | Canada | Unknown status |
| CancerCare Manitoba /ID# 246414 | Winnipeg | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.