NCT05427136Recruiting
Early Pulmonary Dysfunction in Childhood Cancer Patients
Prospective Multicentre Cohort Study of Early Pulmonary Dysfunction in Childhood Cancer Patients (SWISS-Pearl Study)
Source: ClinicalTrials.gov · Last updated 8 May 2026
Brief summary (registry, in English)
This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 140 (estimated)
- First submitted
- 1 Jun 2022
- Start date
- 1 Jun 2021
- Primary completion date
- 30 Jun 2051
- Lead sponsor
- University Children's Hospital Basel
- Diseases
- Childhood cancers
- NCT number
- NCT05427136
What you commit to
- Study type: Observational
- Planned participants: 140
- From 1 Jun 2021 to the primary completion date, 30 Jun 2051
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- In addition for MRI and lung function tests:
- Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)
- Pregnant
- MRI measurement not possible without sedation
- Metal (e.g. pacemaker) in the body
Other illness
- Operation outside the chest area as only cancer treatment
- Relapsed cancer (patients who develop relapse during the study will not be excluded)
Other
- no signed informed consent
Who the study is looking for
- at least one of the following cancer treatments:
- chest radiation
- treatment with any kind of chemotherapy
- hematopoietic stem cell transplantation (HSCT)
- thoracic surgery
- consent for Childhood Cancer Registry (ChCR) registration
Age in the registry: 4 years to 22 years · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Children's Hospital Basel (UKBB) Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| Universitätsklinik für Kinderheilkunde Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Geneva University Hospital Coordinator of this site? Confirm its status | Geneva | Switzerland | Recruiting |
| Centre Hospitalier Universitaire Vaudois Lausanne Coordinator of this site? Confirm its status | Lausanne | Switzerland | Recruiting |
| Universitäts-Kinderspital Zürich Coordinator of this site? Confirm its status | Zurich | Switzerland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.