NCT05431127Completed
High Dose Inspiratory Muscle Training in LOPD
High-dose Inspiratory Muscle Training (IMT) in Late-onset Pompe Disease (LOPD)
Source: ClinicalTrials.gov · Last updated 1 Oct 2025
Brief summary (registry, in English)
Study Objectives: 1) assess the safety and feasibility of high-dose inspiratory muscle training (IMT) delivered remotely in Late-onset Pompe Disease (LOPD) and 2) determine its effects on respiratory and patient-reported outcomes.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 34 (actual)
- First submitted
- 21 Jun 2022
- Start date
- 19 Jul 2022
- Primary completion date
- 1 Jan 2025
- Lead sponsor
- Duke University
- Diseases
- Pompe disease
- NCT number
- NCT05431127
What you commit to
- Study type: Interventional
- Participants enrolled: 34
- From 19 Jul 2022 to the primary completion date, 1 Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior history of gene therapy for LOPD
Other illness
- Presence of medical comorbidities that prevent meaningful study participation (e.g., COPD GOLD III-IV, significant mental illness, dementia)
Other
- Use of continuous invasive or non-invasive ventilation while awake
- Inability to give legally effective consent
- Inability to read and understand English
Who the study is looking for
- Age ≥ 18 years
- Confirmed diagnosis of LOPD
- MIP \>50% of predicted for sex and age
- Stable on current Pompe disease treatment regimen \>6 months
- Able to follow directions for study participation
- Access to computer and smartphone/tablet with reliable internet connection for video visits and sensor-based respiratory technologies
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.