NCT05437653Completed
MRI Based Study to Assess Brain-gut Axis in Obesity
Developing Magnetic Resonance Imaging Techniques to Explore the Brain-gut Axis to Food Intake in People With Obesity and Healthy Weight Participants
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood. Magnetic Resonance Imaging (MRI) is a powerful non-invasive imaging tool that allows studying the function of the brain and gut. The aim of this study is to develop MRI methods to combine brain and gut imaging in a single MRI scan session. The developed techniques will then be used to assess the brain-gut axis to a high fat drink compared with iso-caloric/iso-viscous/iso-volumetric carbohydrate drink in people with obesity and healthy weight participants. The findings could provide a possible explanation for why some people are heavier than others.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 24 (actual)
- First submitted
- 8 Apr 2022
- Start date
- 28 Mar 2022
- Primary completion date
- 1 Apr 2023
- Lead sponsor
- University of Nottingham
- Diseases
- Obesity
- NCT number
- NCT05437653
What you commit to
- Study type: Interventional
- Participants enrolled: 24
- From 28 Mar 2022 to the primary completion date, 1 Apr 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Under medication (expect aspirin/paracetamol), antibiotic or prescribed probiotic treatment in the past 12 weeks.
- Following a medically- or self-prescribed diet during the two weeks prior to the pre-study examination and until the end of the study.
- Participation in another clinical or research study within the previous 3 months of the study
Other illness
- Any reported history of neurological or gastrointestinal disorders
- Any reported history of surgery that could affect gastrointestinal function (e.g. colectomy, small bowel resection)
- Contraindications for MRI scanning i.e. metallic implants, pacemakers, history of metallic foreign body in eye(s) and penetrating eye injury, assessed by standard MRI safety questionnaire.
Lab values
- Laboratory results that are clinically significant, including diabetes, dyslipidemia, pancreatitis, or untreated hypertension.
Other
- Abnormal screening procedures including depression and eat restriction
- Reported weight loss or gain ≥ 10 % of bodyweight during the six months period before the pre-study examination
- Pregnancy or breastfeeding declared by candidate
- Smoking
- Left-handed assessed by handedness questionnaire. This is to control for brain's lateralisation effects (activation in one side of the brain) that may show variations between left and right handed participants.
- Cannot lie flat or exceeding the scanner bed weight limit of 250 kg.
- Poor understanding of the spoken and/or written English language
Who the study is looking for
- Aged 18-45, male and female (females will have the study days arranged during the early phase of the menstrual cycle).
- Body mass index (BMI): normal weight participants ≥ 19 and ≤ 25 Kg/m2, and obese participants \> 30 Kg/m2
- Able to give voluntary written informed consent to participate in the study
- Able to understand the requirements of the study
- Apparently healthy: no medical conditions which might affect study measurements (judged by health questionnaire, and blood screening)
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Nottingham Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.