NCT05441839Recruiting
UK Heart Failure With Preserved Ejection Fraction
UK Heart Failure With Preserved Ejection Fraction Registry
Source: ClinicalTrials.gov · Last updated 6 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 10000 (estimated)
- First submitted
- 26 May 2022
- Start date
- 7 Oct 2022
- Primary completion date
- 1 Jun 2037
- Lead sponsor
- Manchester University NHS Foundation Trust
- Diseases
- Heart failure
- NCT number
- NCT05441839
What you commit to
- Study type: Observational
- Planned participants: 10000
- From 7 Oct 2022 to the primary completion date, 1 Jun 2037
- 26 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- LV EF \< 40% (at screening or any previous measurement)
Other illness
- Known active myocarditis, constrictive pericarditis, or cardiac tamponade
- Known severe primary valvular heart disease
- Known idiopathic, heritable or drug-induced pulmonary arterial hypertension
- Heart transplantation or ventricular assist device
- Complex congenital heart disease
Other
- Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis)
- Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy
- Known arrhythmogenic right ventricular cardiomyopathy
Who the study is looking for
- Written informed consent
- Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse
- Natriuretic peptide levels measured
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (26)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cwm Taf Morgannwg University Health Board Coordinator of this site? Confirm its status | Abercynon | United Kingdom | Recruiting |
| Buckinghamshire Healthcare NHS Trust Coordinator of this site? Confirm its status | Aylesbury | United Kingdom | Recruiting |
| University Hospitals Birmingham NHS Foundation Trust Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Broomfield Hospital Coordinator of this site? Confirm its status | Chelmsford | United Kingdom | Recruiting |
| NHS Tayside Coordinator of this site? Confirm its status | Dundee | United Kingdom | Recruiting |
| Glasgow Royal Infirmary Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
| West Suffolk NHS Foundation Trust Coordinator of this site? Confirm its status | Ipswich | United Kingdom | Recruiting |
| Kettering General Hospital Coordinator of this site? Confirm its status | Kettering | United Kingdom | Recruiting |
| Leeds Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Recruiting |
| University Hospitals of Leicester NHS Foundation Trust Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| Guys and St Thomas NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Barnet Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Imperial College Healthcare NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Manchester University NHS Foundation Trust Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| The James Cook University Hospital Coordinator of this site? Confirm its status | Middlesbrough | United Kingdom | Recruiting |
| Northumbria Healthcare NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Recruiting |
| Norfolk & Norwich University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Norwich | United Kingdom | Recruiting |
| George Eliot Hospital Coordinator of this site? Confirm its status | Nuneaton | United Kingdom | Recruiting |
| North West Anglia NHS Foundation Trust Coordinator of this site? Confirm its status | Peterborough | United Kingdom | Recruiting |
| University Hospitals Dorset NHS Foundation Trust Coordinator of this site? Confirm its status | Poole | United Kingdom | Recruiting |
| Betsi Cadwaldr University Health Board Coordinator of this site? Confirm its status | Rhyl | United Kingdom | Recruiting |
| Salisbury NHS Foundation Trust Coordinator of this site? Confirm its status | Salisbury | United Kingdom | Recruiting |
| Sheffield Teaching Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Recruiting |
| University Hospital of North Tees Coordinator of this site? Confirm its status | Stockton-on-Tees | United Kingdom | Recruiting |
| South Tyneside & Sunderland NHS Foundation Trust Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Recruiting |
| Southend University Hospital Coordinator of this site? Confirm its status | Westcliff-on-Sea | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.