NCT05445219Active, not recruiting
Identifying Therapeutic Hemodialysis Targets Through Cerebrovascular Reactivity; RESPIRACT 2
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
Patients with chronic kidney disease receiving hemodialysis (HD) suffer from higher rates of brain vascular disease and decreased cognition than the general population. One way to assess brain vascular health and response to HD stress, is to test how the brain's blood flow responds to carbon dioxide (CO2) to measure Cerebrovascular Reactivity (CVR). In this study, the investigators will compare the magnitude and speed of the brain's blood flow response to a step-wise change in CO2 with hemodynamic, dialysis, and cognitive parameters. The goal of the study is to establish therapeutic targets that can be altered during the dialysis procedure to protect the brain from HD stress.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 37 (estimated)
- First submitted
- 27 Jun 2022
- Start date
- 20 May 2023
- Primary completion date
- 31 Oct 2024
- Lead sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Diseases
- Chronic kidney disease
- NCT number
- NCT05445219
What you commit to
- Study type: Observational
- Planned participants: 37
- From 20 May 2023 to the primary completion date, 31 Oct 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous neurosurgery
Other illness
- Severe chronic obstructive lung disease (COPD) /Asthma
- History of cerebrovascular accident (stroke, transient ischemic attack)
- History of carotid stenosis or carotid surgery
- History of vasculitis
- Documented Dementia
Other
- Mental incapacity to consent
- Declined to participate
- Pregnancy
- Not fluent in English
Who the study is looking for
- Patients ≥ 18 years old, receiving hemodialysis treatment at least 3 times per week at a London Health Sciences Centre facility
- English proficiency
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.