NCT05457855Completed
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Montelukast vs Fluticasone
Source: ClinicalTrials.gov · Last updated 11 Aug 2025
Brief summary (registry, in English)
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the same indication.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 51533 (actual)
- First submitted
- 11 Jul 2022
- Start date
- 1 Feb 2022
- Primary completion date
- 7 Jul 2023
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Asthma
- NCT number
- NCT05457855
What you commit to
- Study type: Observational
- Participants enrolled: 51533
- From 1 Feb 2022 to the primary completion date, 7 Jul 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- 1\. Prior history of dementia measured anytime prior to cohort entry date
- 2\. Prior history of nursing home admission in the 365 days prior to the cohort entry date
Who the study is looking for
- 1\. Aged \>/= 65 years on the index date
- 2\. No prior use of Montelukast and Fluticasone anytime prior to cohort entry date
- 3\. Enrollment in Medicare Part A, B, and D with no HMO coverage for 365 days prior to and including cohort entry date
- 4\. At least two claims with asthma diagnosis measured 365 days prior to drug init
Criteria the registry did not label
- Please see https://docs.google.com/spreadsheets/d/1u8YFpnMHI5HprhyuY14tIgd1COZcsAWKFlbYCT7aL\_A/edit?usp=sharing or Appendix A (https://drive.google.com/file/d/1uC\_G8TJ1ujoJbas1p1gFaYFzY7Hw7xMq/view?usp=sharing) for full code and algorithm definitions.
- Medicare timeframe: 2008 to 2018 (end of data availability).
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.