NCT05467163Active, not recruiting
Conduction System Pacing Versus Biventricular Pacing After Atrioventricular Node Ablation
CONDUCTion System Pacing Versus Biventricular Pacing After Atrioventricular Node Ablation in Heart Failure Patients With Symptomatic Atrial Fibrillation and Narrow QRS (CONDUCT-AF Trial)
Source: ClinicalTrials.gov · Last updated 29 Apr 2026
Brief summary (registry, in English)
Atrioventricular node ablation (AVNA) with biventricular (BiV) pacemaker implantation is a feasible treatment option in patients with symptomatic refractory atrial fibrillation and heart failure. However, conduction system pacing (CSP) modalities, including His bundle pacing and left bundle branch pacing, could offer advantages over BiV pacing by providing more physiological activation. The randomized, interventional, multicentric study will explore whether CSP is non-inferior to BiV pacing in echocardiographic and clinical outcomes in heart failure (EF \<50%) patients with symptomatic AF and narrow QRS scheduled for AVNA.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 82 (estimated)
- First submitted
- 17 Jul 2022
- Start date
- 18 Jul 2023
- Primary completion date
- 25 Dec 2025
- Lead sponsor
- University Medical Centre Ljubljana
- Diseases
- Heart failure, Atrial fibrillation
- NCT number
- NCT05467163
What you commit to
- Study type: Interventional
- Planned participants: 82
- From 18 Jul 2023 to the primary completion date, 25 Dec 2025
- 10 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe concomitant non-cardiac disease
Other illness
- Pre-existing permanent pacemaker, implantable cardioverter-defibrillator or cardiac resynchronization device. Patients who had devices implanted that had \<5% of paced beats (i.e., backup pacing) can be enrolled.
- Recent (\<3 months) myocardial infarction, percutaneous or surgical myocardial revascularization
- Significant heart valve disease (severe insufficiency or stenosis)
Other
- Life expectancy less than 12 months
- Pregnancy
- Contraindication for oral anticoagulation
- Mechanical tricuspid valve replacement
- Unwillingness to participate or lack of availability for follow-up
Who the study is looking for
- Symptomatic permanent atrial fibrillation, refractory to drug therapy or failed catheter ablation
- Left ventricular ejection fraction \<50%
- Narrow intrinsic QRS ≤ 120 ms
- NT-proBNP \> 600 ng/L
- Patient has provided written informed consent
- Age between 18 years and 85 years
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Graz - Divison of Cardiology Coordinator of this site? Confirm its status | Graz | Austria | Unknown status |
| Hospital Oost-Limburg (Hartzentrum Genk) Coordinator of this site? Confirm its status | Genk | Belgium | Unknown status |
| Acibadem City Clinic Tokuda Hospital - Department of Invasive Electrophysiology Coordinator of this site? Confirm its status | Sofia | Bulgaria | Unknown status |
| Clinical Hospital Center Rijeka Coordinator of this site? Confirm its status | Rijeka | Croatia | Unknown status |
| University hospital of Split Coordinator of this site? Confirm its status | Split | Croatia | Unknown status |
| University Hospital Centre Zagreb Coordinator of this site? Confirm its status | Zagreb | Croatia | Unknown status |
| Central Hospital of Northern Pest - Military Hospital Coordinator of this site? Confirm its status | Budapest | Hungary | Unknown status |
| County Clinical emergency hospital of Brasov - Department of Interventional Cardiology Coordinator of this site? Confirm its status | Brasov | Romania | Unknown status |
| University Medical Centre Ljubljana - Department of cardiovascular surgery Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Unknown status |
| University Medical Centre Ljubljana - Department of cardiology Coordinator of this site? Confirm its status | Ljubljana | Slovenia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.