NCT05468151Active, not recruiting
Cold Acclimation as a Modulator of Brown Adipose Tissue Function in Adults With Obesity
Source: ClinicalTrials.gov · Last updated 11 May 2026
Brief summary (registry, in English)
This study will investigate the effects of at least 12 weeks of weekly cold water immersions (water temperature 18ºC) on BAT perfusion in individuals with obesity. BAT oxygen uptake and tissue perfusion will be measured using 15O-O2 and 15O-H2O PET-CT, at room temperature and after cold exposure. In addition, BAT glucose uptake will be measured using 18F-FDG after 2 hours of cold exposure and BAT NEFA uptake will be analyzed using 18F-FTHA at room temperature. To understrand the metabolic effects of BAT activation in individuals with obesity and how the cold water immersions affect the BAT perfusion in humans is critical for the development of new strategies to treat obesity and its comorbidities.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 19 Jul 2022
- Start date
- 25 Jul 2022
- Primary completion date
- 20 Dec 2024
- Lead sponsor
- Turku University Hospital
- Diseases
- Obesity
- NCT number
- NCT05468151
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 25 Jul 2022 to the primary completion date, 20 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Malignancies
- Immune disorders
- Viral or bacterial infections
- Allergy to lidocaine or epinephrine, or other local anaesthetics
- Any other cardiovascular, pulmonary, orthopaedic, neurologic, psychiatric or other conditions that in the opinion of the local clinician/researcher, would preclude participation and successful completion of the protocol, or that would negatively impact or mitigate participation in and completion of the protocol.
Lab values
- Abnormal cardiovascular status, arrhythmia and/or long QTc in ECG, abnormal cardiac murmur, previous history of cardiovascular disease
Other
- Being regularly exposed to cold environments for the last 3 months (e.g. having a job as a ski monitor, fishmonger, woodcutter, etc.; or doing sports/leisure activities outdoors for prolonged periods of time, etc.)
- Having gone for winter/ice swimming and bathing more than once every 2 weeks during the last 3 months.
- Inability to undergo scanning (e.g., claustrophobia)
- Pregnancy
- Smoking (or use of nicotine based products)
- Hypo/hyperthyroidism
- Weight change (intentional or not) over the last 6-months \> than 5% of body weight
Who the study is looking for
- BMI\>30kg/m2 (for participants with obesity)
- BMI\<25kg/m2 (for lean participants)
- Waist circumference \>94 cm for men (for participants with obesity)
- Waist circumference \> 80 for women (for participants with obesity)
- Glucose ≥7.8 and \<11 mmol/L after OGTT (for participants with obesity)
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Turku PET Centre Coordinator of this site? Confirm its status | Turku | Finland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.