NCT05474235Recruiting
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders
Clinical & Genetic Studies in ALS and Other Neurodegenerative Motor Neuron Disorders
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
The purpose of this study is to collect, from patients with sporadic and familial ALS and their family members, clinical data and blood samples for extraction of DNA, RNA, preparation of lymphocytes, plasma and serum to establish a repository for future investigations of genetic contributions to ALS pathogenesis. Blood samples for DNA extraction also would be collected from control subjects with no personal or family history of ALS phenotypes.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 3000 (estimated)
- First submitted
- 14 Jul 2022
- Start date
- Dec 2007
- Primary completion date
- Dec 2038
- Lead sponsor
- Mayo Clinic
- Diseases
- ALS (motor neurone disease)
- NCT number
- NCT05474235
What you commit to
- Study type: Observational
- Planned participants: 3000
- From Dec 2007 to the primary completion date, Dec 2038
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Personal or family history of dementia or other neurodegenerative disease (Parkinson disease, Alzheimer disease, etc.);
Other
- ALS or Suspected Patient • Limited mental capacity rendering the subject unable to provide written informed consent or assent or comply with standard phlebotomy procedures.
- Blood Relative of ALS Patient
- Limited mental capacity rendering the subject unable to provide written informed consent or comply with standard phlebotomy procedures.
- Healthy Control Subject
- Limited mental capacity rendering the subject unable to provide written informed consent or comply with standard phlebotomy procedures.
Who the study is looking for
- ALS or Suspected ALS Patient
- Clinical diagnosis of possible, laboratory-supported probable, probable or definite ALS according to modified EL Escorial criteria, suspected ALS according to original El Escorial criteria, or diagnosis of a neurodegenerative disorder with evidence of ALS plus extramotor features; OR
- Blood relative (first, second or third degree) with history of ALS or neurodegenerative disorder with evidence of ALS plus extramotor features; OR:
- A clinical suspicion or referral for ALS;
- \> 18 years of age;
- Willing and able to give signed informed consent or assent that has been approved by the Institutional Review Board (IRB).
- Blood Relative of ALS Patient
- Family history (first, second or third degree blood relative) of ALS or other motor neuron disease;
- \> 18 years of age;
- Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB).
- Healthy Control
- No personal or family history (first, second or third degree blood relative) of ALS or other motor neuron disease;
- \> 18 years of age;
- No personal history of other neurodegenerative disease (i.e., Alzheimer disease, Parkinson disease);
- Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.