NCT05477251Not yet recruiting
Comparative Study on the Efficacy and Safety of Microwave Ablation and Lobectomy in the Treatment of Ground Glass Nodules Located in the Pulmonary Hilar Region
Source: ClinicalTrials.gov · Last updated 11 Aug 2022 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
GGO is a characteristic focus of early lung cancer. Due to the abundant peripheral blood vessels and bronchial tissues around the GGO lesions located in pulmonary hilar, only lobectomy could be used for the surgical treat of hilar GGO lesions which will make the significantly decline of the pulmonary function after surgery and affect the quality of life to a great extent. Our previous study has reported a new blunt-tip MWA electrode (MTC-3CA-II3, Vison Medical Inc.) for the treatment of GGO lesions. The blunt-tip MWA electrode could improve the safety of GGO ablation, significantly reduce the occurrence of bleeding and hemoptysis, which made it possible to ablate GGO in the hilar region safely. In this study, the blunt-tip MWA electrode was used in the treatment of patients with hilar GGO lesions, and the efficacy and safety of microwave ablation and lobectomy in the treatment of ground glass nodules located in the pulmonary hilar region were evaluated and compared.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 26 Jul 2022
- Start date
- 1 Oct 2022
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- RenJi Hospital
- NCT number
- NCT05477251
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Oct 2022 to the primary completion date, 31 Dec 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- The lesions had received other treatments before; patients with regional lymph node metastasis or distant metastasis or with pleural fluid and ascites;
Other illness
- The general condition of the patient is very poor, ECOG physical fitness score \> 2, unable to tolerate lobectomy and MWA treatment, or has relevant contraindications;
- Severe heart, lung, kidney, brain and other important organ diseases;
Other
- Patients with poor compliance;
- The researcher believes that it is not suitable for inclusion
Who the study is looking for
- The age ranged from 18 to 75 years old, male or female;
- GGO lesions in the hilar region were diagnosed by imaging examination (CT / PET-CT). During the follow-up of 6-12 months, the lesions increased by more than 2mm, the solid components increased, or there were obvious solid components, or the GGOs were judged to be highly malignant by imaging.
- The size of GGO lesions was 8mm-3cm, and the number of nodules was ≤ 3.
- There was no lymph node metastasis, intrapulmonary metastasis or distant organ metastasis;
- After multidisciplinary evaluation, the patients were feasible for lobectomy and CT guided microwave treatment;
- No bleeding tendency, normal coagulation function or coagulation dysfunction can be corrected after treatment;
- Patients and /or family members agreed to join the clinical trial and signed informed consent.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.