NCT05477862Enrolling by invitation
Neural Mechanisms of Clinically Designed Improvisatory Music for Alzheimer's Disease
Neural Mechanisms of Induced Calmness After Listening to Improvisatory Music: An Investigation for Healthy Individuals and Persons With Alzheimer's Dementia
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
Clinically Designed Improvisatory Music (CDIM) is a form of improvised music based on calm-inducing sound parameters which brought relief to our cohort of neurology patients. As a direct sound-based approach, CDIM does not rely on autobiographical memory and may have wider applicability and generalizability. We wish to examine if CDIM decreases anxiety in 15 cognitively healthy individuals and 15 Alzheimer Disease patients with anxiety (AD-A).
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 17 Jul 2022
- Start date
- 1 Sept 2023
- Primary completion date
- 15 Dec 2026
- Lead sponsor
- Northwestern University
- Diseases
- Alzheimer disease
- NCT number
- NCT05477862
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Sept 2023 to the primary completion date, 15 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals with mild to moderate Alzheimer's disease
- This group will similarly be recruited through the Mesulam Center. All individuals recruited by the research Core at the center are well characterized tests standardized across all NIH funded Alzheimer Centers across the nation. Individuals with mild to moderate neurocognitive disorder due to AD will have an MMSE greater than \>15 and Clinical Dementia Rating (CDR) between 0.5 and 2.. They will also have a history of neurocognitive-related agitation/anxiety, and a Beck Anxiety Index (BAI) or Rating for Anxiety in Dementia (RAID) greater than 8, suggestive of at least a mild level of anxiety.
Who the study is looking for
- Cognitively healthy individuals
- Cognitively healthy control participants evaluated through the Northwestern Mesulam Center. BAI \> 8.
Age in the registry: 55 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mesulam Center for Cognitive Neurology and Alzheimer's Disease Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.