NCT05479721Active, not recruiting
LITMUS Imaging Study
Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & Validation of Imaging Modality Performance Across the NAFLD Spectrum in a Prospectively Recruited Cohort
Source: ClinicalTrials.gov · Last updated 16 Apr 2025
Brief summary (registry, in English)
The LITMUS Imaging Study is a prospectively recruited, observational study of patients with histologically characterised non-alcoholic fatty liver disease (NAFLD). It aims to evaluate the diagnostic performance of imaging biomarkers (ultrasound elastography and magnetic resonance biomarkers) against NAFLD histological scores in a cross-sectional analysis and the natural history of NAFLD in a longitudinal study.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 450 (estimated)
- First submitted
- 26 Jul 2022
- Start date
- 4 Sept 2019
- Primary completion date
- 31 Oct 2025
- Lead sponsor
- University of Oxford
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT05479721
What you commit to
- Study type: Observational
- Planned participants: 450
- From 4 Sept 2019 to the primary completion date, 31 Oct 2025
- 18 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any contra-indication to Magnetic Resonance Imaging (MRI) (e.g. ferrous metal implants/fragments, implantable cardiac defibrillator or permanent pacemaker, metal clips following neurosurgery, pregnancy, other condition that would make MR scanning unsafe in the opinion of the scanner operator)
Other
- Patients that do not speak the language in which the patient information is written will be excluded. Due to the nature of the study, being able to read the information about the study or access to a relevant interpreter is a necessary criterion for participant's safety in regards to MR scanning.
- Patients judged by the investigator to be unsuitable for inclusion in the study (e.g. where the investigator feels that the participant will not be able to comply with the study procedures)
Who the study is looking for
- Recruited to the European NAFLD Registry
- Patient had a liver biopsy less than 3 months prior to enrolment into the study or is having a liver biopsy in less than 3 months' time for the assessment of NAFLD.
- Participant is willing and able to give informed consent for participation in the study.
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Inselspital, University Hospital Coordinator of this site? Confirm its status | Bern | Switzerland | Unknown status |
| Universitätsmedizin der Johannes Gutenberg-Universität Mainz Coordinator of this site? Confirm its status | Mainz | Germany | Unknown status |
| Universitätsklinikums Würzburg Coordinator of this site? Confirm its status | Würzburg | Germany | Unknown status |
| Vall d'Hebron University Hospital Coordinator of this site? Confirm its status | Barcelona | Spain | Unknown status |
| Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocío University Hospital Coordinator of this site? Confirm its status | Seville | Spain | Unknown status |
| HU Clínico de Valladolid Coordinator of this site? Confirm its status | Valladolid | Spain | Unknown status |
| Helsinki University Hospital Coordinator of this site? Confirm its status | Helsinki | Finland | Unknown status |
| Le Centre de Recherche Clinique (CRC) du CHU d'Angers Coordinator of this site? Confirm its status | Angers | France | Unknown status |
| Institut ICAN - Institute of Cardiometabolism And Nutrition Hôpital de la Pitié Salpêtrière Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Addenbrookes Hospital Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Unknown status |
| The Newcastle Upon Tyne Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Unknown status |
| Queens Medical Centre Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Unknown status |
| Oxford University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Laiko General Hospital of Athens Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
| Università di Palermo Coordinator of this site? Confirm its status | Palermo | Italy | Unknown status |
| Department of Medical Sciences University of Torino Coordinator of this site? Confirm its status | Torino | Italy | Unknown status |
| Linkoping University Hospital Coordinator of this site? Confirm its status | Linköping | Sweden | Unknown status |
| Pinnacle Clinical Research Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.