NCT05479994Active, not recruitingPhase 2
Study of BGB-11417 in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of BCL2 Inhibitor BGB-11417 in Adult Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Source: ClinicalTrials.gov · Last updated 4 Mar 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the efficacy of BGB-11417 in participants with relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 100 (actual)
- First submitted
- 27 Jul 2022
- Start date
- 25 Oct 2022
- Primary completion date
- 24 Jan 2025
- Lead sponsor
- BeiGene
- Diseases
- Chronic lymphocytic leukaemia
- NCT number
- NCT05479994
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 100
- From 25 Oct 2022 to the primary completion date, 24 Jan 2025
- 50 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior autologous stem cell transplant (unless ≥ 3 months after transplant) or prior chimeric cell therapy (unless ≥ 6 months after cell infusion)
- Prior allogeneic stem cell transplant
- Note: Other protocol defined Inclusion/Exclusion criteria may apply
Other illness
- Prior malignancy within the past 2 years, except for curatively treated basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast, or low risk (Gleason score ≤ 6) localized prostate cancer
- Underlying medical conditions that, in the investigator's opinion, will render the administration of study drug hazardous or obscure the interpretation of safety or efficacy results
- A known history of or currently suspected Richter's syndrome
Who the study is looking for
- Participants with a histologically confirmed diagnosis of CLL/SLL based on the International Workshop on CLL (iwCLL) criteria:
- Treatment intolerance or failure during or after treatment with chemoimmunotherapy (CIT) and BTK inhibitors (BTKi) or
- Treatment intolerance or failure during or after treatment with BTKi for CIT-ineligible participants as assessed by the investigator.
- Participants who require treatment based on the iwCLL 2018 criteria
- Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 to 2
- Life expectancy of \> 6 month
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (50)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing Jishuitan Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Peking University Third Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Beijing Friendship Hospital, Capital Medical University(Tongzhou) Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The First Hospital of Jilin University Coordinator of this site? Confirm its status | Changchun | China | Unknown status |
| The Second Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| Hunan Cancer Hospital Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| The Third Peoples Hospital of Datong Coordinator of this site? Confirm its status | Datong | China | Unknown status |
| Dazhou Central Hospital Coordinator of this site? Confirm its status | Dazhou | China | Unknown status |
| Peoples Hospital of Deyang City Coordinator of this site? Confirm its status | Deyang | China | Unknown status |
| Fujian Cancer Hospital Coordinator of this site? Confirm its status | Fuzhou | China | Unknown status |
| Zhujiang Hospital of Southern Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
| Affiliated Hospital of Guizhou Medical University Coordinator of this site? Confirm its status | Guiyang | China | Unknown status |
| Hainan Cancer Hospital Coordinator of this site? Confirm its status | Haikou | China | Unknown status |
| Zhejiang Cancer Hospital Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| The First Affiliated Hospital Zhejiang University School of Medicine Coordinator of this site? Confirm its status | Hangzhou | China | Unknown status |
| Anhui Provincial Cancer Hospital aka West Branch of Anhui Province Hospital Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
| The Affiliated Hospital of Inner Mongolia Medical University Coordinator of this site? Confirm its status | Hohhot | China | Unknown status |
| Shandong Cancer Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Shandong Provincial Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Jining No Peoples Hospital West Branch Coordinator of this site? Confirm its status | Jining | China | Unknown status |
| The First Peoples Hospital of Kashgar Coordinator of this site? Confirm its status | Kashgar | China | Unknown status |
| Yunnan Cancer Hospital Coordinator of this site? Confirm its status | Kunming | China | Unknown status |
| Lanzhou University Second Hospital Coordinator of this site? Confirm its status | Lanzhou | China | Unknown status |
| The First Affiliated Hospital of Henan University of Science and Technology Coordinator of this site? Confirm its status | Luoyang | China | Unknown status |
| The First Affiliated Hospital of Nanchang University Branch Donghu Coordinator of this site? Confirm its status | Nanchang | China | Unknown status |
| Jiangsu Province Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Zhongda Hospital Southeast University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The First Affiliated Hospital of Guangxi Medical University Coordinator of this site? Confirm its status | Nanning | China | Unknown status |
| Nanyang Central Hospital Coordinator of this site? Confirm its status | Nanyang | China | Unknown status |
| Ningbo First Hospital Coordinator of this site? Confirm its status | Ningbo | China | Unknown status |
| Quanzhou First Affliated Hospital of Fujian Medical University Coordinator of this site? Confirm its status | Quanzhou | China | Unknown status |
| The Second Affiliated Hospital of Fujian Medical University Donghai Campus Coordinator of this site? Confirm its status | Quanzhou | China | Unknown status |
| Affiliated Zhongshan Hospital of Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Yuebei Peoples Hospital Coordinator of this site? Confirm its status | Shaoguan | China | Unknown status |
| Shengjing Hospital Of China Medical University Coordinator of this site? Confirm its status | Shenyang | China | Unknown status |
| Shanxi Bethune Hospital Coordinator of this site? Confirm its status | Taiyuan | China | Unknown status |
| Institute of Hematology and Hospital of Blood Disease Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| Tonghua Center Hospital Coordinator of this site? Confirm its status | Tonghua | China | Unknown status |
| Affiliated Cancer Hospital of Xinjiang Medical University Coordinator of this site? Confirm its status | Ürümqi | China | Unknown status |
| Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Affiliated Hospital of Jiangnan University South Campus Coordinator of this site? Confirm its status | Wuxi | China | Unknown status |
| Shaanxi Provincial Peoples Hospital Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| The affiliated hospital of xuzhou medical university Coordinator of this site? Confirm its status | Xuzhou | China | Unknown status |
| Northern Jiangsu Peoples hospital Coordinator of this site? Confirm its status | Yangzhou | China | Unknown status |
| Yantai Yuhuangding Hospital Coordinator of this site? Confirm its status | Yantai | China | Unknown status |
| Red Cross Hospital of Yulin City Coordinator of this site? Confirm its status | Yulin | China | Unknown status |
| Zhangzhou Municipal Hospital of Fujian Province Coordinator of this site? Confirm its status | Zhangzhou | China | Unknown status |
| Henan Cancer Hospital Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.