NCT05481827Enrolling by invitationPhase 2
ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the long-term safety of GT005 in participants with Geographic Atrophy (GA) secondary to AMD who have been treated in an antecedent study.
- Status (registry)
- Enrolling by invitation
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 225 (estimated)
- First submitted
- 28 Jul 2022
- Start date
- 12 Jul 2022
- Primary completion date
- 2 Jun 2028
- Lead sponsor
- Gyroscope Therapeutics Limited
- Diseases
- Macular degeneration
- NCT number
- NCT05481827
- EU CT number
- 2024-510946-15-00
- EudraCT number
- 2020-003987-22
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 225
- From 12 Jul 2022 to the primary completion date, 2 Jun 2028
- 32 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Able and willing to give written informed consent
- Received GT005 in an antecedent study, GT005-01 (FOCUS, NCT03846193), GT005-02 (EXPLORE, NCT04437368) and GT005-03 (HORIZON, NCT04566445)
- Willing to attend study visits and complete the study procedures.
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (32)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Melbourne - The Centre for Eye Research Australia (CERA) Coordinator of this site? Confirm its status | Melbourne E. | Australia | Unknown status |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Active, not recruiting |
| Universitaetsklinikum Tuebingen AöR Coordinator of this site? Confirm its status | Tuebingen | Germany | Active, not recruiting |
| Instituto De Microcirugia Ocular Dos S.L. Coordinator of this site? Confirm its status | Barcelona | Spain | Active, not recruiting |
| Clinica Baviera S.A. Coordinator of this site? Confirm its status | Madrid | Spain | Active, not recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Active, not recruiting |
| Centre Hospitalier Universitaire de Dijon Coordinator of this site? Confirm its status | Dijon | France | Active, not recruiting |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Nantes | France | Active, not recruiting |
| The Retina Clinic London Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| South Tyneside and Sunderland NHS Foundation Trust - Sunderland Eye Infirmary Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Unknown status |
| OFTALMIKA Sp. z o.o Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Active, not recruiting |
| Retina Consultants of Austin Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| The Retina Care Center, Llc - Baltimore Location Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Ophthalmic Consultants of Boston (OCB) Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Pepose Vision Institute, P.C - Midwest Vision Research Foundation Coordinator of this site? Confirm its status | Chesterfield | United States | Unknown status |
| Cincinnati Eye Institute Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Texas Retina Associates (Tra) - Dallas Main Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Southwest Retina Research Center Coordinator of this site? Confirm its status | Durango | United States | Unknown status |
| Sterling Vision - Oregon Retina, Llp Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| Vitreo Retinal Associates Pa - the Millennium Center Location Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Retina Consultants of Texas (Retina Consultants of Houston) - Texas Medical Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Midwest Eye Institute Northside Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| University Retina and Macula Associates, P.C. - Lemont Office Coordinator of this site? Confirm its status | Lemont | United States | Unknown status |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Mid Atlantic Retina - Wills Eye Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Rand Eye Institute, Inc. (Rei) Coordinator of this site? Confirm its status | Pompano Beach | United States | Unknown status |
| Retina Consultants San Diego - Poway Coordinator of this site? Confirm its status | Poway | United States | Unknown status |
| Sierra Eye Associates Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Retina Associates of Western New York Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Retinal Consultants of San Antonio (Rcsa) - Medical Center Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Retina Vitreous Associates of Florida Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Wolfe Eye Clinic Coordinator of this site? Confirm its status | West Des Moines | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.