NCT05482126Suspended
Sensory Filtering in the Human Basal Ganglia as a Mechanism of Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 24 Sept 2026
Brief summary (registry, in English)
The investigators are investigating the brain activity associated with sensory information in movement disorders in order to improve treatment of these symptoms beyond what is currently available.
- Status (registry)
- Suspended
- Study type
- Observational
- Enrollment
- 30 (estimated)
- First submitted
- 26 Jul 2022
- Start date
- 8 Jun 2022
- Primary completion date
- 1 Aug 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Parkinson disease
- NCT number
- NCT05482126
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior DBS surgery or ablation
- Unable to withhold dopaminergic medications for at least 12 hours prior to scheduled visit
- Previous diagnosis of PD, other movement disorder, or other significant neurological disease.
Other illness
- Medical contraindications such as current uncontrolled hypertension, heart disease, coagulopathy, or other conditions that might increase the risk of surgery
- Diagnosis or suspicion of atypical Parkinsonism (PSP, MSA, CBD) or drug-induced Parkinsonism, or significant neurological disease other than PD.
- Diagnosis of psychogenic movement disorder based on consensus criteria
Age
- Age \<18 years.
- Clinical dementia and/or Dementia Rating Scale (DRS) score of \<5th percentile adjusted for age and education level, based upon routine pre-op NP testing.
- Age \<18 years.
Who the study is looking for
- Age \>18 years
- Clinically definite, advanced idiopathic PD based on consensus criteria.
- Normal, or essentially normal, preoperative brain MRI.
- Patient is available for follow-up visits over the length of the study
- Patient has elected to undergo DBS surgery as part of routine care, and subthalamic nucleus (STN) is determined as the appropriate surgical target
- Age \>18 years.
- No diagnosis of PD, other movement disorder, or other significant neurological disease.
Age in the registry: 18 years to 89 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Alabama at Birmingham Hospital Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.