NCT05487417CompletedPhase 4
Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy
Effects of Minocycline on Patients With Acute Anterior Circulation Ischemic Stroke Undergoing Intravenous Thrombectomy
Source: ClinicalTrials.gov · Last updated 29 Jul 2026
Brief summary (registry, in English)
Minocycline is the second generation of tetracycline. Because of its lipophilicity, it has high penetrance of blood-brain barrier. Animal model studies have shown that minocycline can reduce cerebral damage after ischemic stroke, and its mechanism involves multiple molecular pathways, such as antioxidant, anti-inflammatory, anti apoptotic pathways, and protection of blood-brain barrier. Clinical studies have also shown that minocycline can significantly improve 3-month National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) of patients with ischemic stroke, indicating that minocycline is a potential neuroprotective drug. Minocycline is believed to protect the blood-brain barrier, thereby reducing the ischemia-reperfusion injury caused by mechanical thrombectomy. However, whether minocycline can become a synergistic treatment method of mechanical thrombectomy, there is no clinical research in this area at present. Therefore, investigators carry out the study on the effect of minocycline in patients with acute anterior circulation ischemic stroke after mechanical thrombectomy, and plan to enroll 180 patients. To explore the safety and effectiveness of minocycline in patients with acute ischemic stroke after thrombectomy.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 189 (actual)
- First submitted
- 30 Jul 2022
- Start date
- 1 Nov 2022
- Primary completion date
- 10 Jun 2025
- Lead sponsor
- Xijing Hospital
- Diseases
- Stroke
- NCT number
- NCT05487417
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 189
- From 1 Nov 2022 to the primary completion date, 10 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- No revascularization therapy was performed during the operation or the TICI score after revascularization therapy was less than 2b;
- Participated in another clinical trial within 30 days before inclusion in the study.
Other illness
- There are other major central nervous system diseases, such as brain injury, brain tumor, multiple sclerosis, etc;
- Known history of congestive heart failure (requiring dietary or medication changes or hospitalization) within 6 months, or myocardial infarction within 6 months;
- There is evidence of any other life-threatening or severe diseases that may hinder the completion of the 3-month follow-up and affect the evaluation of the results;
- Pre-existing neurological deficits or history of dementia;
- There are infectious diseases that require antibiotic treatment before the disease;
- Allergic to tetracyclines or unable to take minocycline for other reasons;
Lab values
- Renal insufficiency or hepatic insufficiency (serum creatinine \>2.0 mg/dL or 180 µmol/L; liver function greater than 3 times the normal value);
Other
- There are contraindications for mechanical thrombectomy;
- There is evidence that the patient has bacterial endocarditis, aortic dissection, arteritis or venous cerebral infarction;
- Minocycline could not be given within 1 hour after recanalization;
- Pregnant patients;
- Refuse to sign the informed consent form.
Who the study is looking for
- Patients with acute cerebral infarction of anterior circulation accompanied by large vessel occlusion;
- Age 18-85 years old;
- The time of onset ≤ 6 hours or ≤ 24 hours suitable for mechanical thrombectomy determined by multimodal imaging;
- The time of onset 6-24 hours, DWI shows an infarct volume less than 1/3 of the MCA blood supply area; the time of onset ≤ 6 hours, the ASPECTS(Alberta Stroke Program Early CT Score) is ≥6;
- Preoperative NIHSS score ranges from 6 to 30 points;
- Sign the informed consent form;
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Xijing hospital Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.